美国密歇根大学博士后—用于癌症药发现的药物化学

美国密歇根大学博士后—用于癌症药发现的药物化学

密西根大学（University of Michigan），也称密西根大学安娜堡校区，简称密大或UMich ，创建于1817年，校本部位于美国密西根州安娜堡市，是一所公立研究型大学，被誉为公立常春藤，入选英国政府“高潜力人才签证计划”。

密西根大学是美国历史最为悠久的研究型大学之一。学校建校于1817年9月24日底特律，1837年将校址迁往安娜堡。密西根大学是美国大学协会十四所创始院校之一，且为创始成员中最古老的公立大学。

Postdoctoral Fellow in Medicinal Chemistry for Cancer Drug Discovery

Employer

University of Michigan - Department of Pathology

Location

University of Michigan, Ann Arbor

Salary

Full time job plus benefits

Closing date

29 Dec 2024

Job Description

Postdoctoral position is available in the laboratory of Prof. Tomasz Cierpicki, University of Michigan, Ann Arbor, to develop small molecule inhibitors for targeted therapies in cancer. We are seeking for highly motivated synthetic organic chemist or medicinal chemist to join a comprehensive drug discovery program. Dr. Cierpicki lab. is conducting highly interdisciplinary research focused on pre-clinical development of novel anti-cancer drugs, which covers medicinal chemistry, structural biology, biochemical and biophysical assays, biological and animal studies. We have a strong team of synthetic chemists to support our drug-discovery efforts. The successful candidate will be involved in designing and synthesis of small molecule inhibitors as potential anti-cancer agents with a major focus on synthesis of heterocyclic compounds targeting protein-protein interactions relevant to cancer. The duties will include design and synthesis of new analogues of existing leads to develop biologically active compounds for testing in cancer cells and animal models of cancer. The candidate must be independent in designing synthetic routes, solving challenging synthetic problems and efficient in synthesizing targeted molecules, including multi-step synthesis.

Requirements

Applicant must have PhD in synthetic organic chemistry or medicinal chemistry and be a first author on at least 2-3 publications. This position requires extensive experience in designing synthetic routes for new classes of compounds, solving challenging synthetic problems and SAR analysis. Applicant needs strong expertise in using HPLC, NMR and MS for organic chemistry applications. Excellent oral and written communication skills in English are required.

How to apply

Please submit cover letter, CV, and contact information for 2-3 references combined into one PDF file by e-mail to: tomaszc@umich.edu

Contact:

Tomasz Cierpicki, PhD, Professor

Department of Pathology, University of Michigan

Ann Arbor, MI, 48109, USA

https://www.pathology.med.umich.edu/index.php?t=page&id=1473

e-mail: tomaszc@umich.edu

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