法国国家卫生研究所(INSERM) 博士后—1型糖尿病的新型调节性T细胞疗法

法国国家卫生研究所(INSERM)博士后—1型糖尿病的新型调节性T细胞疗法

法国国家健康与医学研究院（法文为：Institut national de la santé et de la recherche médicale），简称“Inserm”，成立于1964年，是一所总部位于法国巴黎的国家级公共科学和技术研究机构，其前身是成立于1941年的法国国家卫生研究院，由法国卫生部和研究部共同管理。Inserm是法国唯一一个完全致力于人类健康的公共研究组织，参与从研究到治疗的全过程，其宗旨通过增进对生命和疾病的知识、创新治疗方法和公共卫生研究，促进全人类健康。

Postdoctoral position for EU project ARTiDe: A novel regulatory T celltherapy for type 1 diabetes

Employer

French National Institute for Health Research (INSERM)

Location

Paris, Ile-de-France (FR)

Salary

The postdoctoral salary will be according to experience following INSERM regulation.

Closing date

19 Aug 2024

This project is funded via the European consortium ARTiDe coordinated by S. Fillatreau. ARTiDe involves 8 partners providing novel technologies for the systematic identification of autoantigen-specific Tregs and Teffs in humans, the selection of optimal TCR to produce protective Tregs, innovative humanized T1D pre-clinical models to test their efficacy and safety, the development of industrial process for TCR-engineered Treg production, and new Treg supporting strategies in vivo.

This post-doctoral scientist will work on 1) the molecular characterization of autoreactive Teffs and Tregs at single cell level in patients with T1D and control in order to decipher the basis for the loss of immunological tolerance in this human disease, as well on 2) the evaluation of the selected autoreactive TCR obtained through the single cell studies above for their capacity to produce protective Tregs using a novel humanized model for T1D.

INEM is a biomedical research center including 19 teams and two departments: “Cell Biology (Growth and Signaling)” and “Immunology, Infectiology, and Haematology”. Together with the IMAGINE institute and the Hôpital Necker-Enfants Malades, it makes up the Necker campus which, supported by state-of-the-art core facilities, provides a vibrant environment for basic research and translational innovation. The Campus has a long-standing reputation for scientific excellence (8 principal investigators (PIs) at INEM received ERC awards) and key pioneering medical contributions (e.g. transplantation, biotherapy, gene therapy).

The position is funded for a post-doctoral scientist (3 years).

Please send your application via email in English with CV, a brief outline of previous research, and contact details of three references to: simon.fillatreau@inserm.fr ; simonfillatreau@googlemail.com

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