德国汉堡大学医学中心博士后—癌症中微生物群-宿主相互作用

德国汉堡大学医学中心博士后—癌症中微生物群-宿主相互作用

Postdoc (all genders) on microbiota-host interaction in cancer

Employer

Personalwerk GmbH

Location

Hamburg (DE)

Salary

TBD

Closing date

14 Mar 2025

Postdoc (all genders) on microbiota-host interaction in cancer Full time/ Part time | Temporary | Arbeitsort: Hamburg Eppendorf

UKE_Zentrum für Onkologie

Better together. For life.

At, we are committed to excellence in research, education, and comprehensive healthcare across our clinics. Every day, our team of approximately 15,300 dedicated employees works to make the world a healthier place. Our goal is to be one of the leading university hospitals while also being the best employer in our industry.

At UKE, we believe that meaningful and successful work should align with our employees' personal needs and individual lifestyles. Just as diverse as these needs are, so too is the variety of personalized solutions we offer.

Welcome to the UKE.

Main tasks

The microbiota comprises the collection of microorganisms inhabiting specific locations, such as the human intestine. It is shaped by environmental influences and nurtured by diet. Certain microbiota profiles are strongly associated with cancer and the outcomes of cancer therapies. But how do they impact the host?

We hypothesize that the microbiota influence the host by degrading dietary components to produce metabolites, which may act locally in the gut or reach distant cancer sites through circulation. Recently, we discovered that a specific microbiota-derived metabolite can modulate the response to chemotherapy in pancreatic cancer models (Tintelnot et al., Nature, 2023).

We are seeking a motivated and innovative candidate with a passion for science and the curiosity to think outside the box. Your goal will be to advance our understanding of microbiota-host interactions in the context of cancer. Your expertise will be key to uncovering the molecular mechanisms behind microbiota-mediated effects on cancer and therapy resistance.

This position is temporary for three years, with the possibility of extension.

Your Profile

Completed academic studies in chemistry, biology, biochemistry, human biology or related subjects

Profound knowledge in operating and establishing new methods on a LC/MS

Profound knowledge in either chemistry (drug design, chemichal modification of metabolites), clinical immunology, microbiota, cancer biology or cancer metabolism

Prior knowledge in bioinformatic analysis of multi-omic data and/or work with laboratory mice is preferred

High degree of intrinsic motivation

Our Offer

Attractive compensation according to TVöD/VKA

Secure employment with meaningful work and respectful collaboration

Comprehensive onboarding and open knowledge exchange within the team

Extensive training and further education programs at our UKE Academy for Education and Careers

Opportunities to contribute to our “UKE INside” personnel policy through cross-professional and cross-hierarchical projects

Sustainable travel: subsidies for the Deutschlandticket as a job ticket, and Dr. Bike bicycle service

Family-friendly working environment: cooperation on childcare, free vacation childcare, advice for employees with relatives in need of care

Excellent health, wellness, and sports programs

A wide range of dining options in our staff restaurant, with additional choices available at the “Health Kitchen” cafés, bistros, and an on-site supermarket

Access to cutting-edge technologies and equipment

Full-time access to state-of-the-art LC/MS equipment

Weekly one-on-one meetings with the PI to ensure guidance and progress

Access to human material for translational studies and a range of sophisticated mouse models (germ-free mice, cancer models, immune cell reporter mice), as well as advanced multi-omics platforms (single-cell sequencing, metabolomic screening, shotgun metagenomics) and corresponding bioinformatics pipelines

Daily scientific exchange through lab meetings, topic meetings, and journal clubs

A strong national and international collaboration network

A dynamic, interdisciplinary team of scientists from diverse fields including medicine, biology, microbiology, and physiology

Contact

We look forward to receiving your complete appli­cation by 14th March 2025.

APPLY NOW >

Contact to the department

Dr. Joseph Tintelnot

j.tintelnot@uke.de

Recruiting contact

Recruiting Team

+49 (0) 40 7410-52599

Please note that employment is contingent upon proof of immunization or immunity against the measles virus, in accordance with applicable legal and medical requirements. Documentation (e.g., vaccination certificate) must be provided before employment begins.

We live diversity and value variety

We offer a work environment that provides equal opportunities regardless of age, gender, sexual identity, disability, ethnic and social origin, or religion. This is confirmed by our accession to the Charter of Diversity. We explicitly aim to increase the proportion of women in management positions, especially among scientific personnel in research and teaching. Women with equal qualifications will be given priority. The same applies in the case of under-representation of one gender in the advertised area. Persons with severe disabilities with equal aptitude, competence, and professional performance will be given priority.

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