英国利兹大学结构生物学博士后

英国利兹大学结构生物学博士后

利兹大学（University of Leeds），是一所位于英格兰西约克郡利兹市的公立研究型大学，QS世界大学排名位列世界第82名，是罗素大学集团成员， [66]同时也是世界大学联盟、 [75]国际大学气候联盟、 [76]英联邦大学协会、RENKEI、英国大学联盟、N8大学联盟、 [79]白玫瑰大学联盟、 [82]中欧商校联盟、 [80]中英大学工程教育与研究联盟等组织成员。

Research Fellow in Structural Biology

Faculty of Biological Sciences, The University of Leeds

Application Deadline:20 November 2024

Job Salary £39,105 to £48,485 Grade 7

Contact Name Contact: Professor Sheena Radford

We are looking for an outstanding research fellow to join our interdisciplinary team that is investigating how proteins aggregate into amyloid fibrils, and how fibrils with different structure perturb cellular function. This BIRAX-funded role is to use cryoEM, supported with other biochemical and biophysical analyses, to understand the structure of amyloid fibrils formed in vitro and purified from patient samples and to determine the activity of different fibril types in causing neuronal dysfunction. This will help to reveal the mechanisms by which disease-relevant mutations and post-translational modifications effect changes in amyloid aggregate formation and the consequences of aggregation on cellular function.

You will be based in the laboratories of Professors Sheena Radford and Neil Ranson, and work closely with other members of our amyloid team. The work will be carried out in collaboration with Professor Raz Jelinek (Ben Gurion University) who has recently shown an activity of amyloid fibrils in the degradation of neurotransmitters. You should have a PhD (or be close to completing one) in Structural Biology, Biochemistry, or a related discipline, and extensive experience of using structural methods to elucidate biological mechanisms. Experience in cryo-electron microscopy would be a significant advantage, but training will be given to outstanding structural biologists lacking this experience but able to evidence their passion and commitment to learn cryo-EM techniques.

Please note that this post may be suitable for sponsorship under the Skilled Worker visa route but first-time applicants might need to qualify for salary concessions. For more information please visit: www.gov.uk/skilled-worker-visa.

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