英国约克大学博士后职位—血液学和肿瘤学

英国约克大学博士后职位—血液学和肿瘤学

约克大学（University of York），建于1963年，位于英国英格兰约克，是一所公立研究型大学。

约克大学是英国罗素大学集团、世界大学联盟、N8大学联盟、白玫瑰大学联盟和江苏—英国高水平大学联盟成员。该校校友中有15位英国议会议员。

约克大学位列2023QS世界大学排名162位，2024THE世界大学排名第147位。

Postdoctoral Researcher in Haematology and Oncology

University of York

Department

Biology

Salary

£36,024 per year

Grade

Grade 6

Contract status

Fixed term

Hours of work

Full-time

Based at

University of York campus

Interview date

To be confirmed

Posted Date

04/03/2024

Apply by

25/03/2024

Job Reference

13185

Documents

13185 Job Description.pdf (PDF, 302.53kb)

Role Description

We are looking for a talented and motivated full-time Postdoctoral Research Associate (PDRA) to join the group of Dr William Grey based in the Centre for Blood Research, York Biomedical Research Institute, Department of Biology, University of York. The Grey lab focuses on the proteome and the role of protein homeostasis in healthy haematopoiesis and malignant transformation to acute myeloid leukaemia (AML), with a particular interest in using primary patient material and translating fundamental biological findings to therapeutic target. We especially encourage applicants with a strong interest in proteomics and molecular biology to apply.

The post is full time, on a fixed term basis for an initial period of 3 years funded by the Medical Research Council (MRC).

Role

We study the leukaemic stem cell (LSC) compartment of AML using both inducible mouse models (Cancer Cell 2016) and primary patient samples (Sci. Transl. Med. 2022), with a particular focus on the functional state of the proteome (Blood 2020). In this new project, funded by the MRC, we will study how the proteome evolves from healthy haematopoietic stem cell to malignant leukaemic stem cell in vivo.

The successful candidate will benefit from a highly collaborative programme with academic and clinical interactions in the U.K. and Europe including; Prof. David Kent (York, U.K., HSC biology), Dr. Anjum Kahn (Leeds, U.K., Consultant haematologist), Prof. Cristina Lo Celso (London, U.K., in vivo imaging), Dr. Andrew Wood (Edinburgh, U.K., degron tagging), Prof. Jurg Schwaller (Basel, Switzerland, inducible mouse models) and Dr. Marieke Essers (Heidleburg, Germany, HSC stress integration). The post holder will also benefit from a multidisciplinary environment locally at the Centre for Blood Research (Fielding, Kent, Hitchcock, Bridge) and colleagues in Chemistry (Fascione, Spicer). The post holder will be expected to balance driving their independent research project alongside managing mouse models and xenograft cohorts for a longitudinal project with a long-term view to research. They will also work closely with other lab members and researchers across the institute and take an active role in proposing PhD projects, supervising students and developing potential new areas of research in the lab.

Skills, Experience & Qualification needed

PhD in a biomedical sciences discipline, or equivalent experience in haematology, immunology or cancer cell biology.

Experience in cell culture and molecular biology techniques (e.g. PCR, qPCR, western blotting and flow cytometry).

Experience in using in vivo mouse models, primary stem cell cultures, primary human material and proteomics is desirable.

Experience of carrying out both independent and collaborative research, writing up research work for publication and a willingness to contribute to the process of securing future research funding.

Interview date: To be confirmed

For informal enquiries: please contact Dr William Grey at william.grey@york.ac.uk

The University strives to be diverse and inclusive – a place where we can ALL be ourselves.

We particularly encourage applications from people who identify as Black, Asian or from a Minority Ethnic background, who are underrepresented at the University.

We offer family friendly, flexible working arrangements, with forums and inclusive facilities to support our staff. #EqualityatYork

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