英国牛津大学博士后职位—帕金森病的新型基因疗法

英国牛津大学博士后职位—帕金森病的新型基因疗法

牛津大学（University of Oxford），简称“牛津”（Oxford），位于英国牛津，是一所公立研究型大学，采用传统学院制。是罗素大学集团成员，被誉为“金三角名校”、“G5超级精英大学”，全球大学校长论坛成员。

Postdoctoral Research Scientist

University of Oxford

United Kingdom

March 15, 2024

Contact:N/A

Offerd Salary:Negotiation

Location:N/A

Working address:N/A

Contract Type:Fixed term for 2 yea

Working Time:Full time

Working type:N/A

Ref info:N/A

Postdoctoral Research Scientist

Department of Physiology, Anatomy and Genetics, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, Parks Road, Oxford, OX1 3PT

Full-time/Fixed term for 2 years

Applications are invited for a Post-Doctoral neuronal cell and molecular biologist to work on a new project to develop a novel gene therapy for Parkinson's in patient stem cell-derived neurons. The project, in collaboration with Kaleibe Therapeutics and Replay (https: // replay.bio), represents an exciting opportunity to undertake translation work into biological therapeutics at the interface between academic and industrial research in an exceptional setting. This work will develop novel gene therapies for Parkinson's by expression of complete genomic DNA transgenes from HSV1 viral vectors to correct cellular phenotypes in induced pluripotent stem cell (iPSC)-derived dopamine neurons generated from Parkinson's patients.

Duties will include the design, generation and delivery of HSV1 gene expression vectors to in vitro models of Parkinson's to study phenotypic correction; maintenance and differentiation of iPSC-derived neurons and cell lines; undertaking laboratory experiments; interpretation of data; imaging analysis; preparation of data for publication; contribute to wider project planning and determine the most appropriate methodologies to test hypotheses. You will have excellent practical experience of neuronal cell cultures and DNA gene expression plasmid vectors, and a good knowledge of cellular models of neurodegenerative disease. The ability to innovate, trouble-shoot technical problems, be meticulous in practical work and in record keeping is essential.

Applicants must hold, or be near completion of, a PhD in a relevant area of research and have experience in cellular neuroscience or molecular cell biology relevant to analysis of neuronal phenotypes in vitro and in vivo.

The post is available for two years to start as soon as possible. The post will be based in the Laboratory of Molecular Neurodegeneration, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, Parks Road, Oxford, OX1 3PT

Informal enquiries may be directed Professor Richard Wade-Martins (richard.wade-martins@dpag.ox.ac.uk).

Closing date for applications is midday on Friday 15th March 2024. Interviews are likely to be held the week beginning 25th March 2024.

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.

While this is a full-time role, we welcome applications from individuals who wish to be considered for part-time working or other flexible working arrangements.

We, as a Department and Community, will be considerate and welcoming of all people, regardless of age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex, sexual orientation, gender identity, and socio-economic background. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion

Contact Person : HR Team Vacancy ID : 171179 Contact Phone : 01865 282167 Closing Date & Time : 15-Mar-2024 12:00 Pay Scale : STANDARD GRADE 7 Contact Email : hr@dpag.ox.ac.uk Salary (£) : 36024 - 44263

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