法国国家健康与医学研究院（INSERM）博士后–遗传性肌肉疾病的基因组编辑

法国国家健康与医学研究院（INSERM）博士后–遗传性肌肉疾病的基因组编辑

法国国家健康与医学研究院（法文为：Institut national de la santé et de la recherche médicale），简称“Inserm”，成立于1964年，是一所总部位于法国巴黎的国家级公共科学和技术研究机构，其前身是成立于1941年的法国国家卫生研究院，由法国卫生部和研究部共同管理 [1]。Inserm是法国唯一一个完全致力于人类健康的公共研究组织 [2]，参与从研究到治疗的全过程，其宗旨通过增进对生命和疾病的知识、创新治疗方法和公共卫生研究，促进全人类健康。

Postdoctoral Researcher – Genome Editing For Inherited Muscular Disorders

Universities and Institutes of France

France

October 31, 2023

Contact:N/A

Offerd Salary:Negotiation

Location:N/A

Working address:N/A

Contract Type:Other

Working Time:Full time

Working type:N/A

Ref info:N/A

27 Aug 2023

Job Information

Organisation/Company

INSERM

Research Field

Biological sciences

Researcher Profile

Recognised Researcher (R2)

Country

France

Application Deadline

31 Oct 2023 - 23:00 (UTC)

Type of Contract

To be defined

Job Status

Full-time

Hours Per Week

To be defined

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

A postdoctoral position is available in the therapeutic genome editing team under the direction of Dr. Mario Amendola in Genethon, biopark of Evry, France and it is funded by the Horizon Europe (https: // magic-horizon.eu/). This project deals with neuromuscular and musculoskeletal disorders, which are amongst the most frequent causes of disability in Europe. These genetic diseases are characterized by severe skeletal muscle wasting, impaired mobility, reduction of quality of life and premature death. Although supportive treatments are in clinical practice to manage symptoms, there is still no cure for muscular dystrophies. Thus, the overarching objective of our project is the generation of innovative models of human skeletal muscle disorders to develop, screen and validate new neuromuscular gene therapy vectors and genome editing strategies with high efficacy and selective tropism coupled with low toxicity and limited immunogenicity. Relevant publications below. Our laboratory focuses on: 1) developing effective and safe genome editing and gene therapy strategies for the treatment of human genetic diseases, in particular muscular disorders, hemoglobinopathies and lysosomal storage; 2) understanding of these pathologies and their molecular mechanisms; 3) understanding DNA repair and how to modulate/exploit to improve efficacy and safety of genome editing tools.

Where to apply

Website

https: // jobrxiv.org/job/inserm-27778-postdoctoral-researcher-genome-editing- for…

Contact

Website

https: // www. linkedin.com/feed/update/urn:li:activity:7100978153208061952/

STATUS: EXPIRED

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