美国耶鲁大学招聘有机合成和化学生物学博士后

Postdoctoral Associate in Organic Synthesis and Chemical Biology : New Haven, United States

Job details

Employer: Yale University

 

Location: New Haven, United States

 

Expires: September 10, 2014

 

Job type: Postdoctoral

 

Salary: $40,000 - $55,000

 

Qualifications: Postgraduate - Doctorate/PhD

 

Employment type: Temporary

 

Job hours: Full-time

Postdoctoral position in the Department of Chemistry at Yale University

We seek a highly motivated, independent candidate to contribute to our efforts to synthesize novel natural product-derived DNA damaging agents and study their interactions with DNA. This is a unique, interdisciplinary position that will provide the candidate with a broad exposure to organic synthesis, small molecule-DNA interactions, and preclinical studies.

Candidates with experience in organic synthesis or the study of DNA-small molecule interactions will be considered.

Primary responsibilities will involve the study of small molecule–DNA interactions by biophysical methods (fluorescence intercalator displacement assays, melting point assays, etc.), NMR spectroscopy, and/or crystallography. These will be complemented by organic synthesis efforts to prepare improved agents with higher potency and cleavage activity. In collaboration with other laboratories, we conduct preclinical studies of our best compounds, and the successful candidate will be part of this team.

A PhD in organic chemistry (or a related field) and a track record of success (as evidenced by first author publications in high profile journals) are required.

Experience in the study of small molecule–oligonucleotide interactions by NMR or crystallography is highly desirable. Competence in basic microbiology techniques is desirable.

The initial appointment will be for one year with the opportunity to renew, subject to approval. Salaries are tied to the NIH payscale and are commensurate with postgraduate experience.

Comprehensive benefits are provided….