英国塞恩斯伯里实验室招收分子生物学博士后

Research Associate : Norwich, United Kingdom

The first layer of plant innate immunity relies on the recognition of microbes via the perception of pathogen-/microbe-associated molecular patterns (PAMPs/MAMPs) by surface localized receptors called pattern recognition receptors (PRRs). In the plant model Arabidopsis thaliana, the leucine-rich repeat RKs (LRR-RKs) FLS2 and EFR are the PRRs for bacterial flagellin (or flg22) and elongation factor Tu (or elf18), respectively. Within seconds of PAMP binding, FLS2 and EFR form a ligand-induced complex with the regulatory LRR-RK SERK3/BAK1 leading to phosphorylation of both proteins. FLS2 and EFR also forms a constitutive complex with the membrane-associated cytoplasmic kinase BIK1 that get phosphorylated in a BAK1-dependent manner upon PAMP binding. BIK1 is a positive regulator of several FLS2- and EFR-mediated responses. We have recently deciphered some of the mechanisms controlling PRR activation at the plasma membrane and regulating intracellular signalling (Macho et al., Science 2014; Kadota et al., Molecular Cell 2014).

We are now seeking a Post-doctoral Scientist to characterize further some of these processes. Candidates should be highly motivated individuals with a PhD degree in molecular plant genetics. They must have a strong background in molecular biology, biochemistry, and plant/pathogen interactions, and must have published at least one first-author publication.

Salary will be within the UEA Research and Analogous staff Grade 7 scale at between £30,122 and £35,938 pa; the appointment level will reflect qualifications, skills, knowledge and achievements. The positions are offered for 2 years in the first instance. Applicants should provide a CV, including the names and contact details of two referees, and a covering letter addressing the selection criteria. Please send formal applications, quoting the reference number below, either by e-mail to HR@tsl.ac.uk or by post to Kim Blanchflower, HR Manager, The Sainsbury Laboratory, Norwich Research Park, Norwich.

Ref: CZ13/2014 Closing date: 20th June 2014