巴西圣保罗大学招收细胞生物学博士后

Research associte : SAO PAULO, Brazil

Biomarkers of redox misbalance induced by UVA and VIS radiation on XPC fibroblasts and melanocytes

Area: Biochemistry
PI: Mauricio da Silva Baptista
Department of Biochemistry, Institute of Chemistry, USP, Brazil.

Abstract: Protection of human skin against sun exposition is a complex issue that involves ambivalent aspects of the interaction of light with tissues. Both UVA and visible radiation causes redox misbalance and cell damage. UVA is considered a class I carcinogen while visible is not, although our and other research groups have provided evidence that it should be considered as such. One of the problems that hinders the proper characterization of the effects of radiation in both UVA and visible is the lack of molecular knowledge that links redox misbalance and mutagenic DNA products. On this project we will use cells models that tend to accumulate the products of redox misbalance because of the lack of DNA repair (XPC fibroblasts) and because of the generation of a stronger burst of redox misbalance (melanocytes with over-expression of melanin). We will use these extreme conditions to identify by mass spectrometry biomarkers that can link the redox misbalance with the mutagenicity.

Background expected from the applicant: experience with cellular biochemistry and mass spectrometry.

Selection: Based on the analysis of CV and letters of recommendation.
Documents for application: Letter justifying interest for the project, cv, copy of doctorate certificate, recommendation letters.

Send application to: Prof. Mauricio S. Baptista at baptista@iq.usp.br