Structure and function of pseudokinase KSR’s allosteric activation of MEK/B-Raf in RAS-ERK signalling

Introduction

At AstraZeneca We are seeking talented scientists who are interested in pursuing an academic-style Postdoc in a global pharmaceutical setting and contributing to AstraZeneca’s commitment to delivering innovative medicines. This newly expanded internal pharmaceutical Postdoctoral research program spans multiple therapeutic areas and a wide range of scientific disciplines.

Your comprehensive training program includes a focus on drug discovery and development, as well as exposure to existing local and global Postdoctoral Research communities within AstraZeneca. Postdoctoral scientists will have the opportunity to conduct independent cutting-edge work in state-of-the-art laboratories while teaming with other AstraZeneca scientists.

Each Postdoctoral scientist will also be able to collaborate with a leading academic advisor who will provide further support and guidance. Additionally, the Postdoc will be encouraged to attend and present at international scientific conferences and publish high-profile papers.

Accountabilities/Responsibilities

• Conduct structural studies of the ternary complex of KSR/MEK/B-raf.

• Rational design of protein constructs in order to purify components of the ternary complex

• Work closely with associated Post-Doc assigned to study ATP kinetic studies of KSR.

• Communicate results both within AstraZeneca via global working groups and externally at meetings and through publications.

• Work collaboratively with other experts internally within Discovery Sciences Structural and Biophysics department and externally with academic co-supervisors.

• Publish scientific papers in high impact journals.

Minimum Requirements – Education and Experience

• A PhD in one or more of the following areas:

• Protein Crystallography and Structure Determination with CCP4 software (Mandatory)

• Baculovirus protein expression and purification.

• Oncology knowledge with understanding of cellular signalling and/or tumour metabolism.

• Strong interpersonal, organizational and communication skills.

• Proven ability to independently design and execute incisive experiments and interpret results.

Additional skills – any of these would be important

• Experience in the use of SPR would be highly desirable
Preferred experience/requirements

• A strong scientific track record, as evidenced by published or accepted papers in recognized peer-reviewed journals, oral and/or poster presentations at scientific meetings.

• Strong passion & commitment to science, and ability to work well within a group/team environment.

Skills & Capabilities

Review the standard role profile and capture any additional critical knowledge, skill and experience demands relative to this specific role (e.g. if Programme Manager for SAP consider previous experience of executing SAP projects)

Add references to specific leadership, core or professional capabilities which will be recruited against and integral to the job.

An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, national origin, or protected veteran status and will not be discriminated against on the basis of disability….