美国波士顿儿童医院博士后职位—细胞表面受体和跨膜信号转导

美国波士顿儿童医院博士后职位—细胞表面受体和跨膜信号转导

波士顿儿童医院，始建于1869年，一家非盈利医疗机构。

Special Postdoctoral Fellow in Cell Surface Receptors and Transmembrane Signaling

Employer

Springer Lab at BCH

Location

Boston, Massachusetts (US)

Salary

$78,000/annually + benefits

Closing date

Mar 24, 2025

Join the Lab of Tim Springer

Tim Springer, a leader in integrin biology, invites aspiring scientists to join his lab to advance groundbreaking research in integrin transmembrane signaling, TGF-β activation, cell surface receptor mechanobiology, and therapeutic development. This role offers mentorship and opportunities to establish a strong scientific foundation for launching an independent research career.

About the Role:

As a Special Postdoctoral Fellow, you will:

Pursue cutting-edge research in areas such as:

Novel integrin ligands to drive stem cell and organoid development

Cryo-EM: Activation of integrins and TGF-β, and ligand binding

Mechanobiology: Integrin force transduction in rolling adhesion and firm adhesion and TGF-β activation

Single Molecules: Utilize advanced techniques including FRET and magnetic tweezers to explore conformational change kinetics and force transmission in integrins and selectins

Innovative ReaLiSM: (Receptor and Ligand in Single Molecules) to study receptor-ligand binding dynamics

TGF-β Activation: Research localized activation at cell surfaces for new therapeutic targets

Own and Develop Your Project: We encourage candidates to propose and develop their own research ideas, which they can carry forward to establish their own labs.

Key Techniques and Approaches:

Single-molecule imaging

Cryo-EM

Organoid and stem cell research

FRET reporters using non-canonical amino acids

Magnetic and laser tweezers

Mechanobiology and therapeutic target discovery

Why Join Us?

Mentorship from Tim Springer, renowned for his pioneering work in integrins and cell biology

Independence and Growth: Develop projects that will empower your transition to an independent research career

Collaborative Environment at Harvard Medical School and Boston Children’s Hospital

Application Details: To apply, please email the following to springer_jobs@crystal.harvard.edu with "Special Postdoctoral Fellow" in the subject line:

Cover letter (include a brief outline of your project interests)

CV

Three references

Salary: $78,000 annually

Qualified applicants will receive consideration without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status, or disability.

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