美国波士顿儿童医院博士后—细胞表面受体与跨膜信号传导

美国波士顿儿童医院博士后—细胞表面受体与跨膜信号传导

波士顿儿童医院，始建于1869年，一家非盈利医疗机构。

Special Postdoctoral Fellow in Cell Surface Receptors and Transmembrane Signaling

Employer

Springer Lab - PCMM - Boston Children's Hospital

Location

Boston, Massachusetts (US)

Salary

$78,000/annually + benefits

Closing date

11 Jan 2025

Join the Lab of Tim Springer

Tim Springer, a leader in integrin biology, invites aspiring scientists to join his lab to advance groundbreaking research in integrin transmembrane signaling, TGF-β activation, cell surface receptor mechanobiology, and therapeutic development. This role offers mentorship and opportunities to establish a strong scientific foundation for launching an independent research career.

About the Role:

As a Special Postdoctoral Fellow, you will:

Pursue cutting-edge research in areas such as:

Novel integrin ligands to drive stem cell and organoid development

Cryo-EM: Activation of integrins and TGF-β, and ligand binding

Mechanobiology: Integrin force transduction in rolling adhesion and firm adhesion and TGF-β activation

Single Molecules: Utilize advanced techniques including FRET and magnetic tweezers to explore conformational change kinetics and force transmission in integrins and selectins

Innovative ReaLiSM: (Receptor and Ligand in Single Molecules) to study receptor-ligand binding dynamics

TGF-β Activation: Research localized activation at cell surfaces for new therapeutic targets

Own and Develop Your Project: We encourage candidates to propose and develop their own research ideas, which they can carry forward to establish their own labs.

Key Techniques and Approaches:

Single-molecule imaging

Cryo-EM

Organoid and stem cell research

FRET reporters using non-canonical amino acids

Magnetic and laser tweezers

Mechanobiology and therapeutic target discovery

Application Details: To apply, please email the following to springer_jobs@crystal.harvard.edu with "Special Postdoctoral Fellow" in the subject line:

Cover letter (include a brief outline of your project interests)

CV

Three references

Salary: $78,000 annually

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