英国癌症研究中心(CRUK)苏格兰研究所白细胞动力学实验室博士后职位

英国癌症研究中心(CRUK)苏格兰研究所白细胞动力学实验室博士后职位

Postdoctoral Research Scientist- Dr Carlin

Cancer Research UK

Job description

Scotland Institute Lab: Leukocyte Dynamics Lab (Carlin)

Project Title: Neutrophils and cellular senescence: A vicious circle promoting age-related disease.

About us

The CRUK Scotland Institute is a cancer research institute situated in Glasgow with approximately 250 researchers split across 30 research groups consisting of PIs, postdoctoral scientists, PhD students and scientific officers. It is one of Europe's leading cancer research centres, supporting cutting-edge work into the molecular mechanisms of cancer development. As well as core support from Cancer Research UK, the Institute also receives an additional third of its total income from external grants and industry collaborations. It has an excellent reputation for fundamental cancer research, including world-class metabolism studies and renowned in vivo modelling of tumour growth and metastasis. Its research ethos is about excellence, honesty, openness, accountability and integrity.

Project outline

A postdoctoral position is available for an ambitious, creative and translationally minded scientist to join the Carlin group (https: // www. crukscotlandinstitute.ac.uk/cruk-si-research/cruk-si-research- groups/leo-carlin-leukocyte-dynamics.html) as part of an exciting multi- disciplinary project between the Mann (Newcastle), Bird (Glasgow), Sansom (Glasgow) and Carlin (Glasgow) groups at the Scotland Institute.

This new MRC-funded project extends an established and productive partnership between these teams to interrogate the role and regulation of neutrophils in liver disease (e.g., https: // doi.org/10.1136/gutjnl-2021-326259). Building on previous work (https: // doi.org/10.15252/embj.2020106048) which implicates neutrophils in the development of liver senescence, we will now generate mechanistic understanding of the relationship between liver ageing and inflammation.

You will use sophisticated genetic models of senescence and provide detailed characterisation of the immune and non-immune cellular response using a multi- parameter flow cytometry / transcriptomic / imaging approach. You will be supported by a group of scientists with expertise in these cutting-edge approaches including world class researcher-led facilities (https: // www. crukscotlandinstitute.ac.uk/advanced-technologies.html). A dedicated bioinformatics post will work alongside you to maximise output.

You should hold a PhD in immunology or a related discipline with an interest in ageing and cellular senescence. Experience in high parameter single cell techniques including flow cytometry and mouse in vivo work would be highly desirable but we are happy to develop the right candidate. Enthusiasm and drive for the work are essential. This is a multi-lab project so the ideal candidate would be accountable for delivering the goals of the project with an appropriate level of independence and teamworking. Great communication skills will be key to doing this successfully.

We will review and contact promising candidates before the closing date, so please apply as soon as you are ready.

For informal enquires please contact Leo Carlin (leo.carlin@glasgow.ac.uk).

Postdoc support

Postdocs are key members of our research community, and we offer them a range of opportunities to train and develop as researchers while they are with us:

  Exciting, innovative cancer research projects in state-of-the art labs

  A highly collaborative and interactive research environment

  Access to and training in key advanced technologies, for example imaging and in vivo modelling

  A mentor enabling scheme to aid personal and professional development

  A rich programme of scientific exchange through seminars, workshops and meetings

  Support to make fellowship and small grant applications, including during their transition to their next position

  Guidance and mentoring to compete for an independent scientist position as well as a multitude of other career options, including in industry.

  A highly engaged postdoc forum, providing peer support, training, careers advice and regular social events

Equality, Diversity and Inclusion

Our overarching research ethos at the Institute is about excellence, honesty, openness, accountability and integrity. The diversity of our staff and students is also what makes the Institute such a vibrant place to work and advance discoveries in cancer research. Family friendly policies, our collaborative ethos, a focus on good mental health and well-being and opportunities for all help to create an enjoyable and inclusive workplace where your voice matters.

The Institute is also committed to increasing the number of female scientists at the postdoc level and beyond and encourages female applicants to apply. We have recently introduced a highly attractive maternity policy which provides 12-18 months support and funding for postdocs wishing to take time off to spend with their children amongst other family friendly policies.

Employee Benefits

  Competitive salary

  40.5 days annual leave including bank holidays (pro-rata)

  Defined Contribution pension scheme

  Life Insurance scheme

  Employee Assistance Programme

  Season ticket loan

  Additional maternity pay at 6 month's full pay (subject to service)

  Shared parental leave

  Cycle to work scheme that could save you 26-40% on a bike and accessories.

  Access to Employee benefit schemes with discounts on supermarkets, cinema, travel and much more.

  On-site secure parking

Closing Date for Applications: 28th June 2024 but we may contact promising candidates on a rolling basis, so please apply as soon as you are ready.

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