美国凯斯西储大学癌症研究博士后研究员

美国凯斯西储大学癌症研究博士后研究员

凯斯西储大学（Case Western Reserve University），简称CWRU，位于俄亥俄州的克里夫兰，美国私立研究型大学，也是美国大学协会（The Association of American Universities，简称AAU）早期的成员之一。

Postdoctoral Fellow in cancer research

Employer

Case Western Reserve University--GI cancer research

Location

Cleveland, Ohio (US)

Salary

standard NIH-recommended postdoc salary levels

Closing date

Jun 1, 2024

We are a highly translational laboratory studies colorectal (CRC) and pancreatic (PC) cancers with a focus in liver metastases and the tumor microenvironment (TME). The lab (PI, Rui Wang, PhD) is at Case Western Reserve University, Case Comprehensive Cancer Center, Cleveland, OH. Current focus:

Characterize roles of liver stromal cells (endothelium, hepatocytes, and others) in GI cancer liver metastases growth, response to chemotherapy, metabolism, and other pro-survival pathways (e.g. HER3)

Combination therapies of targeting HER3- and other pro-survival pathways

Cancer-liver stromal cell crosstalk.

The candidate will lead on projects to determine the effects of liver endothelial cells (EC), immune cells, and other TME cell types, on primary tumors and liver metastases in CRC and PC. Lab work will involve tissue culture; patient tissue handling (cryo-preserving, isolating primary cells, developing organoids and PDXs); DNA, RNA, and protein-related assays; cell growth and death assays; animal work (xenograft tumor models, PDX, breeding); basic transcriptomics, proteomics, and metabolomics analysis. Additionally, studies will interface with experts in pathology, biostatistics, medicinal chemistry and other specialties. The candidate is expected to prepare manuscripts and contribute preliminary data, background and significance and experimental design for grant proposals. Under the guidance of the PI, the candidate should be able to work independently, read and critically interpret the literature, assist with designing and planning of projects, oversee collaborations, supervise students, manage animal models, and to carry out research on the assigned project. The candidate is encouraged to apply for grants and present at local and national meetings. Importantly, the fellow must work well with others, and have a desire to help cancer patients as a principal motivation for their work.

More infomration about the PI and lab: https://case.edu/cancer/members/member-directory/rui-wang

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