美国加州大学洛杉矶分校博士后职位—视网膜生物化学和临床疾病建模

美国加州大学洛杉矶分校博士后职位—视网膜生物化学和临床疾病建模

加利福尼亚大学（University of California），简称“加州大学”或“UC”，是美国加利福尼亚州拥有十所校区的大学系统。

加州大学起源于1853年建立在奥克兰的加利福尼亚学院（College of California），1868年3月正式更名为“加州大学”。1873年，学校迁入新址，为了纪念18世纪哲学家乔治·贝克莱，新的大学城被命名为“伯克利市”，此后逐渐在洛杉矶等地开设分校区。1952年起，“加州大学”作为一个行政系统逐渐与伯克利加州大学分离。与此同时，加州各地的分校也逐渐升格为与伯克利平级的校区。

Postdoctoral Fellow Retina Biochemistry and Clinical Disease Modeling Laboratory

University of California Los Angeles

Job Description

The UCLA Stein Eye Institute and Department of Ophthalmology invite applications for postdoctoral scholars to work on basic science and translational research projects in The Retina Biochemistry & Clinical Disease Modeling Laboratory. Radu group focuses on studying the retinal pigment epithelium (RPE) in normal and pathological status pertinent to Stargardt disease and age-related macular degeneration.

Research:  Current studies are directed towards understanding the intercellular organelle dynamics in the RPE centered on lysosomes maturation, recycling of retinoids and lipids relevant to cell bioenergetics (mitochondria), and identification of complement-mediated signaling pathways in aging and disease status. Projects will include in vivo studies utilizing novel mouse models and in vitro biochemical and electrophysiological approaches to investigate disease pathology in a “disease-in-a-dish” model. Experiments will involve cutting-edge cell and molecular biology techniques including differentiation of iPSCs and iPSC-derived RPE cells, spatial transcriptomes/ multiomics analysis, and advanced microscopy imaging tools.

Qualifications: The position is for a highly motivated PhD, MD, or MD/PhD who aims to develop an independent research career. The postdoctoral fellow will lead research projects, execute experiments and analyze data, write manuscripts and present at scientific meetings.

Requirements

• Knowledge of and experience with mouse genetics, cell and molecular biology, and basic biochemistry techniques are required for this position.

• A strong background in stem cell biology, in vitro differentiation of iPSCs, and RNASeq/single cell transcriptome analysis are preferred. Experience in confocal microscopy, advanced molecular biology, genomic data analysis, and mammalian cell culture are highly desirable. Specific training in retinoids biochemistry related to visual processes will be offered during the fellowship.

• Candidates must possess strong communication skills, ability to work independently and in a team setting, display self-initiative and attention to detail, enthusiasm to explore new techniques and concepts, and adherence to highest ethical principles while working with laboratory animals.

• Individualized mentorship is tailored to their personal career and publications goals. Successful candidate will participate in weekly lab meetings, seminar series (both our Institute and UCLA), as well as national and international specialized conferences. Regular meetings with the PI will reassure common scientific expectations are met, and skill-building and advance knowledge in the field are achieved.

Apply:  Interested applicants should email an updated CV, complete contact information for 3 references, cover letter describing published and ongoing work, and a statement of future research interest (1-2 pages) to: Roxana Radu (radu@jsei.ucla.edu).

- The Cultural North Star was developed by members of our community and affirms our unswerving commitment to doing what’s right, making things better, and being kind. These are the standards to which we hold ourselves, and one another.   https://medschool.ucla.edu/cultural-north-star

- The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. UCLA has programs to assist in partner employment, childcare, schooling and other family concerns.

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