法国巴斯德研究所博士后职位—提高mRNA疫苗的稳定性

法国巴斯德研究所博士后职位—提高mRNA疫苗的稳定性

法国巴斯德研究所成立于1887年，是一个公益型私人基金会。其职能是致力于对疾病的预防和治疗的科学研究、培训和其它公共卫生行为。它既是生物学基础性研究中心、大学后教学中心（研究与诊断培训），又是专门的生物医学中心、传染病专科住院中心、热带病理学和免疫系统疾病中心。巴斯德研究所包括一个历史展馆、一个科学展馆和一个新建的以图书馆为主体的科学信息中心。

Postdoc Position - Increasing the Stability of mRNA Vaccines

Institut Pasteur

Paris, France

A postdoc position for a talented postdoctoral researcher is available in the Bioorganic Chemistry of Nucleic Acids unit of the Pasteur Institute, Paris, France.

Topic

mRNA vaccines have advanced as a major player in the response against the global pandemic caused by the spread of the SARS-CoV2 virus and might be used to prevent the emergence or expansion of other diseases. However, mRNA vaccines consist of hundreds of natural ribonucleotides and are thus prone to hydrolysis during production, storage, and within the cytosol. Hence, the aim of the project is to include chemical modifications into the scaffold of mRNA vaccines in order to prolong their residence times and efficiencies and also to facilitate their production and ease of storage.

Profile

A PhD in bioorganic chemistry, organic chemistry, or chemical biology with experience in synthesis of RNA nucleoside, nucleotide, and oligonucleotide analogs. The candidate should also have knowledge in enzymatic synthesis of RNA oligonucleotides.

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