美国密苏里大学生物化学方向博士后

美国密苏里大学生物化学方向博士后

密苏里大学（University of Missouri），简称“UM”，1839年创建于美国密苏里州中部城市哥伦比亚，是当时密西西比河西岸唯一的大学。该校现已发展成为著名的密苏里州大学系统，拥有四个校区，分别是哥伦比亚校区（Columbia）、罗拉校区（Rolla）、堪萨斯城校区（Kansas City）和圣路易斯校区（St. Louis），共有学生约63,000名。因在历史上密苏里大学创建于密苏里州哥伦比亚市，所以密苏里大学通常又特指密苏里大学哥伦比亚分校。

Post-doc/staff openings: AAV structure, cell entry & gene therapy

Employer

University of Missouri - Biochemistry

Location

Columbia, Missouri (US)

Salary

Competitive, commensurate with experience.

Closing date

Mar 9, 2024

Discipline

Life Sciences, Biophysics, Computational Biology, Structural Biology, Virology

Position Type

Full Time

Job Type

Postdoc, Research Scientist, Staff Scientist

Organization Type

Academia

Post-doctoral and staff positions are open for structural studies of AAV, the gene therapy vector, and its host cell interactions, and separately, for computer methods development.  Adeno-associated virus is the leading vector for human gene therapy and recently approved in treatments of SMA and hemophilia A & B. Our studies of AAV entry and trafficking advances fundamental virology and lay a key foundation in further development of gene therapies.  Following our X-ray structure of AAV and identification of host factor dependencies through genome-wide screens, we have solved cryo-EM structures of complexes with the entry receptor.  Focus is now on the trafficking of AAV into the nucleus.  Those with training in any area of structural biophysics or molecular biology are welcome to apply.  Those with experience in software engineering can be considered for separate research into cryo-EM structure refinement methods.  Appointments at the University of Missouri can be as post-doctoral fellows or as research staff with a supervisory role, depending on experience.  Applicants should visit https://chapman.missouri.edu/openings/ and apply to the position of interest using the link provided.  A CV should be uploaded with a cover letter briefly summarizing research experience and interests, and with the contact details for three referees.  Applications will be reviewed until the positions are filled.  Enquiries should be directed to Michael Chapman (biochemchair@missouri.edu).

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