美国希望之城博士后职位---疱疹病毒疫苗开发

美国希望之城博士后职位---疱疹病毒疫苗开发

希望之城国家医疗中心(City of Hope NationalMedical Center)是一所顶尖的美国非盈利研究和治疗中心，专注于癌症、糖尿病和其他危及生命的疾病。

Postdoctoral Fellow - Herpesvirus Vaccine Development

City of Hope

Job Description

The laboratory of Javier Gordon Ogembo, Ph.D.at The Beckman Research Institute of City of Hope is looking for a talented Postdoctoral Fellow.

Our laboratory invites highly motivated candidates to apply for an interdisciplinary postdoctoral fellow position. Our laboratory focuses on oncogenic herpesviruses, in particular Epstein-Barr virus (EBV), Kaposi-sarcoma associated herpesvirus (KSHV), and the rhesus macaque EBV homologue rhesus lymphocryptovirus (rhLCV), and on developing prophylactic and therapeutic strategies against primary infection with these viruses and their associated cancers.

The postdoctoral fellow will work on projects with the overarching goal of  designing and testing gamma herpesvirus vaccine candidates and immuno-therapeutics in various preclinical animal models.

The postdoctoral fellow will be leading projects that are in collaborations between the City of Hope Cancer Center and other institutions within and outside the USA. Importantly, City of Hope has good laboratory practice (GLP) and Current Good Manufacturing Practice (cGMP) FDA-approved biologic facilities (https://www.cityofhope.org/research/biological-and-cellular-gmp-manufacturing-facility/cbg---center-for-biomedicine-and-genetics) to produce the candidate vaccines and immunotherapeutics in house and test them in preclinical animal models and in Phase I clinical trials.

Basic education, experience and skills required for consideration:

·         Candidates should have a Ph.D., Ph.D./M.D, M.D., or Ph.D./DVM, with a record of peer-reviewed publications.

·         Molecular biology, protein expression, purification, crystallization, and functionalization.

·         Generation and characterization of monoclonal antibodies for diagnostic and therapeutic purposes.

·         In vitro methods for assessing immunological responses, particularly antibody assays (such as ELISA, isolation/depletion of antigen-specific antibodies, viral neutralization assays, etc.), T cell response and toxicity assays.

·         In vivo immunization and/or tumor investigations, specifically murine (transgenic and humanized), rabbit and NHP models.

·         Ability to design and execute laboratory experiments, critically interpret experimental results, and present data in a clear and concise manner

·         Ability to participate in the preparation of grant applications, scientific publications and investigational new drug applications.

·         Good organization, excellent writing and oral communication, and ability to work in an interdisciplinary team are essential.

Additional information:

·         For more information about Dr. Javier Gordon Ogembo’s lab, please visit here.

·         As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

Salary / Pay Rate Information:

Pay Rate: $31.00 - $34.23 / hour

Contact:

Dr. Javier Gordon Ogembo, david.volsky@mssm.edu

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