美国密歇根大学博士后职位---急性淋巴细胞白血病的靶向疗法

美国密歇根大学博士后职位---急性淋巴细胞白血病的靶向疗法

密歇根大学（University of Michigan），全称密歇根大学安娜堡分校，简称密大或UMich ，创建于1817年，位于美国最佳宜居城市密歇根州安娜堡，是一所公立研究型大学，被誉为公立常春藤。

密歇根大学安娜堡分校是美国历史最为悠久的研究型大学之一。该校建校于1817年9月24日底特律，1837年将校址迁往安娜堡 。创校时间早于密歇根州创立的年份（1837年）。密歇根大学是著名北美顶尖大学联盟美国大学协会十四所创始院校之一，且为创始成员中最古老的公立大学。

Research fellow

University of Michigan

Job Description

The University of Michigan in Ann Arbor ranks #3 in the United States in research and development expenditures at ~$1.5 billion annually. Ann Arbor is a mix of city and rural spaces and is ranked on several lists as the #1 or #2 place to live especially for affordable living and for families. Public school, arts and culture, food, and outdoor green spaces are highly ranked. If you like urban living, walk 5-10 minutes to work. If you like wide open spaces, spend only a 10-minute drive to work instead of 1 hour.

https://www.mlive.com/life/2023/02/michigan-college-town-ranked-the-no-1-best-place-to-live-in-america-in-2023.html

https://fortune.com/well/ranking/best-places-families/2022/ann-arbor/

Job summary:

There are approximately 5,800 new cases of acute lymphoblastic leukemia (ALL) per year. The survival rate of adults with ALL has remained at 30-40%. ALL kills more children than any other cancer. Our goal is to identify and study the network of transcription factor genes and regulatory elements of ALL in order to develop novel targeted therapies that are more effective and less toxic than current medicines. We are looking for a postdoc (research fellow) to study transcriptional regulation of Notch-driven ALL and T-cell regeneration at super-enhancers with a goal to develop the fundamental science needed to improve the effectiveness and safety of current cancer therapies and regenerative medicine.

Specific methodologies:

-Leukemogenesis and T-cell development assays (flow cytometry sorting and analysis; histology; bone marrow transplantation; intrathymic injections; retroviral transduction and transplantation; in vitro stromal cell culture; transplantation in NSG mice)

-Transcriptional genomics (ChIP-Seq/ATAC/4C-Seq library preparation; analyses of RNA/ChIP/ATAC-seq datasets using computational pipelines; bioinformatics)

-Transcription factor/enhancer functional screens and assays (CRISPRi; ChIP; MPRAs)

-Protein-protein interaction biochemistry (mass spectrometry; BIOID; NMR; co-IP; reverse-ChIP)

Model systems:

- Genetically engineered mouse models

- Human leukemia patient-derived xenograft models

- Human and mouse leukemia cell lines

Specific responsibilities:

-Design, perform, analyze, and interpret experiments with training and supervision from PI and other lab members in line with skill set and with goal of independence

-Work as a team with other lab members (PI, bioinformaticist, postdocs, PhD students, and the lab manager/work-study students)

-Collaborate with members of other labs

-Write manuscripts for publication

-Present posters and talks at research conferences

Required Qualifications:

#PhD in a biomedical field

Please send your CV to:

markchia@med.umich.edu

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