凯斯西储大学膜蛋白疾病方向招收博士后

　　凯斯西储大学膜蛋白疾病方向招收博士后

　　The Department of Physiology & Biophysics at Case Western Reserve University School of Medicine seeks a highly motivated postdoctoral scholars to conduct research in the laboratory of Dr. Tingwei Mu.

　　The lab focuses on proteostasis maintenance of membrane proteins in the central nervous system. Membrane protein folding and misfolding is an emerging field in the medical science field. We use a combination of neuroscience, cell biology, biophysics, and electrophysiology approaches to study how the proteostasis network regulates the folding, degradation, assembly, trafficking and function of neuroreceptors both in vitro and in vivo. Another research focus of the lab is the development of therapeutics that correct the misfolding of pathogenic ion channels, as a therapeutic strategy for the treatment of such protein conformational diseases, including neurological and neurodegenerative diseases.

　　The successful applicant will participate in projects on elucidating molecular basis of ion channel protein quality control in the endoplasmic reticulum. The qualified candidate will also be part of our drug discovery project for neurological diseases. The posted position will be supported by a newly funded NIH R01 grant. Competitive salary will be provided and commensurate with experience.

　　The applicant must have a PhD and/or MD degree in neuroscience, cell biology, molecular biology, biochemistry, biophysics, pharmacology, or related field. One postdoc position is in the field of electrophysiology with experience on patch clamping in mammalian cells, neurons, and brain slices. The other one is in cell biology, biophysics, or neuroscience. Previous experience with fluorescence imaging, endoplasmic reticulum biology, mouse genetic models, or neuroreceptors-related research is highly desired, but not required.

　　Interested individuals should send a cover letter, CV, and the names/phone numbers of three people who could provide letters of reference by email to tingwei.mu@case.edu.