凯斯西储大学神经退行性疾病方向博士后招聘

　　凯斯西储大学神经退行性疾病方向博士后招聘

　　Job Description

　　Two postdoc positions are immediately available in the laboratory of Dr. Xin Qi in the department of Physiology & Biophysics at Case Western Reserve University School of Medicine.

　　The lab focuses on mitochondrial pathology in neurodegenerative diseases including Alzheimer’s, Parkinson’s, Huntington’s disease and ALS. We use a combination of in vitro cell culture, in vivo transgenic animal models and patient-derived neurons to study the mechanisms by which mitochondrial impairment contributes to neurodegeneration. Another research focus of the lab is the development of therapeutics that enhance mitochondrial function, for the treatment of human diseases. We have been using the rationally designed peptide inhibitors of protein-protein interactions and high throughput screening to identify mitochondrial functional enhancers as therapeutic options.

　　The successful applicant will participate in NIH-funded projects on elucidating the molecular basis of mitochondrial quality control with our novel transgenic mouse models of neurodegenerative diseases. The qualified candidates will also be part of our drug discovery program for neurodegenerative diseases. The applicants must have a PhD and/or MD degree in neuroscience, molecular biology, cell biology, pharmacology, or related field. Candidates with experience in neurodegenerative diseases and transgenic mouse models are highly desired.

　　Interested individuals should send a cover letter, CV, and the names/phone numbers of three people who could provide letters of reference by email to xxq38@case.edu. Please visit our lab website at https://xinqilab.com/ for additional information