Postdoctoral Research Scientist : Glasgow, United Kingdom

Postdoctoral Research Scientist

Starting Salary from £30,000 to £39,800 (Depending on experience)
Initial 3 year fixed term contract.

Cancer Research UK Beatson Institute in Glasgow is one of Europe's leading cancer research centres. It supports cutting edge research into the molecular mechanisms of cancer development. The Institute provides an outstanding research environment, underpinned by state-of-the-art core services and advanced technologies.

This post is funded through a multi-faceted industrial collaboration and will investigate the role of RAC andRAL-GTPases in both CRC and PDAC. It will involve close interaction with team members across multiple sites.

Testing the functional requirement for RAC and RAL signalling downstream of KRAS mutation in pancreatic and colon cancer. Prof Owen Sansom

KRAS is commonly mutated in both colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC). KRAS mutation initiates nearly all PDAC whilst in CRC KRAS mutation occurs after APC mutation to drive progression. Although much work has concentrated on the MAPK and PI3-Kinase signalling pathways downstream of RAS activation, the work of our group (and others) suggest that both RAC and RALare very important nodes (see Myant et al Cancer Cell 2013). You will use state of the art in vitro and in vivo modelling and imaging as well as established biochemistry and molecular biology. A relevant PhD is required and in depth knowledge of cancer biology and/or in vivo modelling would be advantageous.