英国Francis Crick研究所分子免疫学博士后职位

Postdoctoral Training Fellow - Molecular Immunology : London, United Kingdom

Postdoctoral Training Fellow
Molecular Immunology
This is a full time, fixed term contract for 3 years.

Context

The Francis Crick Institute is a partnership between Cancer Research UK, the Medical Research Council, the Wellcome Trust, UCL (University College London), Imperial College London and King's College London. It is a registered charity whose purpose is to conduct biomedical research into all aspects of human health and disease.

The institute will be a world-leading centre of biomedical research and innovation. It will promote connections between researchers and disciplines and between academic institutions, healthcare organisations and businesses. Dedicated to research excellence, the institute will have the scale, vision and expertise to tackle the most challenging scientific questions underpinning health and disease. It will be world-class with a strong national role—training scientists and developing ideas for public good. Due to open in 2015, the Crick will be located in a new, purpose built research centre in Brill Place, St. Pancras and will house some 1,500 staff.

The position of Postdoctoral Training Fellow has been created to join Dr. Mark Wilson and his team in the the division of Molecular Immunology studying the role of CD4+ T cells in human and murine allergy and asthma. Specifically, you will carry out an independent research project (with supervision) to identify the stability, specilisation and utility of regulatory T cells (TREG) in various models of experimental allergy and human asthma. A strong in-vivo cellular immunology background is desirable, with a good understanding of molecular biology, large panel multi-colour flow cytometry.

Objectives
Specific objectives will include, but not be limited to:
• Be able to carry out world-class independent and team-based research.
• Be able to design sound cellular, ideally T cell, immunological experiments to test hypothesis driven research.
• Be able to investigate molecular immunological mechanisms of T cell stability and flexibility.
• Be able to analyze large RNA-Seq data and large data sets.
• Be comfortable with in-vivo immunology.
• Contribute to writing manuscripts and reviews.
• Provide supervision for other colleagues.
• Engage with research collaborations both externally and within the institute where appropriate.
Person Specification
The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegiate, in addition to the following:

Essential
• PhD or equivalent in research in appropriate area.
• Proven track record of high quality research in cellular immunology as evidenced by publication record.
• Extensive knowledge and practical application of flow cytometry.
• Experience with animal models of disease, aseptic techniques for primary murine cell isolation and culture.
• Experience generating and analysing stably transfected cell lines.
• Previous practical experience, and good theoretical knowledge of T cell biology.
• Experience in investigating gene function by RNA interference (RNAi).

Desirable
• Experience designing constructs for new animal models.
• Experience working with human samples.
• Experience working with small compound screens.