爱尔兰国家生物工艺研究培训所招聘博士后

Advanced Biopharmaceutical Technologies – ‘Facility of the Future’, The Plastic Factory, Enabling Single Use Technologies’**

The Position:
As a postdoctoral research associate in the NIBRT Characterisation and Comparability Laboratory you will join a multidisciplinary team whose focus is to develop and apply new analytical technologies to enable a better understanding of mammalian cell bioprocessing through complete process and product characterisation. The NIBRT Characterisation and Comparability Laboratory is seeking a highly motivated and talented postdoctoral research associate to join the team on an externally funded collaborative research project. Working closely with the Principal Investigator, you will develop and standardise methods for the qualitative and quantitative analysis of extractable and leachable (E&L) compounds from single use components used in industrial bioprocessing. You will apply these methods to evaluate whether the effects of standard manipulations performed during usage, i.e., wet or dry welding, light exposure, sterilisation or rinsing prior to inoculation have any effect on the repertoire of E&L compounds extracted from these plastic components. You will also evaluate large scale extraction, purification and or synthesis of identified E&L compounds to facilitate subsequent toxicity testing, process and product interference analysis and analytical method interference analysis in collaboration with other project team members. You will also create and populate a web database with identified E&L compounds from different single use technology components to serve as a public resource for extractable compound annotation within industry.

Your Profile:
Applicants must hold a PhD in analytical chemistry, organic chemistry, polymer chemistry, bioanalytical chemistry or a related discipline. Applicants who have submitted their research thesis for examination will also be considered provided they can provide evidence of a confirmed date for their viva voce examination. Proven experience demonstrated through peer-reviewed publication of analytical methods, in particular liquid chromatography mass spectrometry based methods, for the structural elucidation of small molecules or process contaminants is essential. Experience within the biopharmaceutical industry or a demonstrated understanding of biomanufacturing processes including mammalian cell culture, therapeutic protein expression and protein purification are highly desirable. A flexible work approach, ability to work effectively within an international, multidisciplinary team and a demonstrated commitment to excellence are essential. You will be expected to present your results at international conferences and publish in high impact peer-reviewed journals.

What We Offer:
This externally funded postdoctoral research position offers a highly competitive salary in accordance with the guidelines of the funding agency. This position is available from 1st October 2014 for up to three years. This position will be based in the award winning NIBRT facility which is located on the University College Dublin Campus in Dublin 4. For more information about NIBRT and for a virtual tour of the facility, check out www.nibrt.ie

More Information:
Informal enquiries can be made to Dr. Jonathan Bones by email: jonathan.bones@nibrt.ie

Application Procedure:
To apply for this position please email your CV, a one page motivation statement and contact details for two academic referees, one of which must be your PhD advisor, in a single combined PDF document to Ms. Barbara Keegan, NIBRT HR Administrator (barbara.keegan@nibrt.ie). Emails of application should be marked ‘your name – Postdoc Research Position’ in the subject line. The closing date for receipt of applications is 1 pm Dublin local time on Thursday September 18th 2014. NIBRT is an equal opportunities employer.l opportunities employer….