美国马萨诸塞州综合医院招聘计算机表观基因学和染色质生物学方向博士后

A joint research position in Computational Epigenomics and Chromatin Biology is available immediately in the Department of Molecular Biology, Massachusetts General Hospital, Boston, MA and the Department of Molecular Biology, Cell Biology and Biochemistry, Brown University. The successful candidate will join the groups of Dr. Michael Tolstorukov and Dr. Erica Larschan to study the role of epigenetic mechanisms and chromatin structure in coordinate gene regulation. The unique placement of the position will provide the candidate with an opportunity to bridge the experimental and computational research and to gain a unique level of expertise in both fields.
Recent advances in high-throughput technologies, including Next Generation sequencing, have greatly facilitated the research into genome organization, ranging from precise mapping of nucleosomes and transcription factors to capturing three-dimensional chromosome conformation. Due to the large amount of the data produced in such experiments, they involve intensive computational analysis. The successful candidate will take responsibility for the analysis of multiple types of sequencing data, including ChIP-Seq, mRNA-Seq, etc. Also, most of the projects will require integration of data from epigenetic, expression, and other studies, both publicly available and newly generated.

The position title will be determined based on the qualifications of the candidate and is expected to be at the level of Postdoctoral Researcher. However, exceptional candidates with a Master’s degree will also be considered. Initial appointment will be for one year with the possibility of extension based on progress evaluation. The ideal candidate will have:
- a Ph.D. or M.S. in Bioinformatics, Computational Biology or a related field
- substantial experience in the analysis of genomic data
- experience in biochemistry or molecular biology is a big plus
- track record of publications in peer-reviewed journals
- extensive scientific programming skills: working knowledge of R and Perl is essential; proficiency in C/C++ and Java is a plus
- experience with UNIX/Linux operating systems
- excellent communication skills and willingness to work in a collaborative team with both computational and bench scientists.

Both Massachusetts General Hospital, which is a teaching affiliate of Harvard Medical School, and Brown University provide outstanding environments for biomedical research and the successful candidate will have ample opportunities to work with the top scientists in the field.