Post-doc Position in Statistical Genetics, Institut Pasteur : Paris, France

POSTDOCTORAL POSITION IN STATISTICAL GENETICS
Open position at Institut Pasteur (Paris, France)

PROJECT: In the framework of the LabEx consortium « Milieu Intérieur » (MI; website: http://www.milieuinterieur.fr/en), a post-doctoral position in statistical genetics is open from September 2014 at the Institut Pasteur in Paris. The goal of the MI consortium is to define the naturally-occurring variation of the human immune responses to an unprecedented scale. Transcriptomic, proteomic and flow cytometry profiles are being defined in response to more than forty immune stimuli and pathogens, in a large cohort of 1000 healthy individuals. The integration of these datasets with the degree of genome-wide variation of the human genome, variation in microbiota, and a large number of demographic variables will allow to evaluate the respective impact of genetic, environmental and sociocultural factors on the inter-individual variability of the immune response, which in turn can account for differences in susceptibility to infectious disease, and response to therapeutic treatment and vaccines.

QUALIFICATIONS: The applicant should have a PhD in Biostatistics, Bioinformatics or Statistical Genetics. The candidate will be responsible for data analyses in the context of this project and will work in a multidisciplinary team that integrates human genetics, immunology, evolutionary genetics and systems biology. This ambitious project needs cutting-edge and innovative methods for the statistical analyses of the data. We look for a candidate with strong experience in large-scale data analyses (data mining), and advanced tools in statistical inference (e.g., linear and generalised linear models, multivariate statistics, Bayesian statistics, MCMC algorithms, etc.). We expect the candidate to have a strong interest in the development of new statistical approaches. Knowledge of genomics and biology is not necessary but will be appreciated. Team spirit and dynamism are essential.

WORK PLACE: Unit of Human Evolutionary Genetics (head: Lluis Quintana-Murci; website:www.pasteur.fr/research/heg), Institut Pasteur, CNRS URA3012, Paris, France. In very strong collaboration with the Center of Human Immunology (head: Matthew Albert), Institut Pasteur, INSERM U818, Paris

SALARY: Salary will depend on previous experience.

CONTACT: To apply, please send your CV and a letter describing your research interests and skills (in a single pdf file) to Dr Etienne Patin, by e-mail: epatin@pasteur.fr…