美国俄克拉荷马医学研究基金会招聘复杂疾病基因学和表现基因学方向博士后

We are seeking a Post-doctoral Fellow to lead investigative studies on the genetic and epigenetic mechanisms of autoimmune diseases. The laboratory is currently investigating the genetic and epigenetic mechanisms of autoimmune susceptibility genes involved in the ubiquitination pathway including TNFAIP3, TNIP1, UBE2L3 and several others. While the genetic associations in these genes are confirmed, the causal variants that are responsible for SLE susceptibility are unclear. In addition, the regulatory mechanisms that result in disordered expression of these genes in the context of disease are not known. We are therefore seeking a highly talented and motivated individual to join our NIH funded laboratory and to lead investigation into the genomic and epigenomic mechanisms that influence the expression and function of these genes in the context of autoimmunity.

Our laboratory employs a wide variety of analytical techniques in the effort to identify causal variants including high-throughput sequencing of DNA, RNA, methylation and histone marks, electrophoretic mobility shift assays, chromosome conformation capture, ChIP-PCR, mass spectrometry, and genome engineering using site-specific engineered nucleases.

Strong candidates will demonstrate proficiency in creative thinking, designing experiments independently, interpreting assay results, summarizing findings, and assisting with manuscript preparation, grant writing, supervising graduate students and presenting data at national meetings.

Oklahoma Medical Research Foundation (OMRF) ranked 3rd in nation in The Scientist magazine's 2013 listing of Best Places to Work for post-docs. Post-doctoral Fellows receive high quality mentoring in a uniquely collaborative team environment in addition to enrichment programs specifically designed to assist post-docs in achieving their career goals. Post-doctoral Fellows work in well funded state-of-the-art laboratories, and receive comprehensive employee benefits. Oklahoma City is one of the most affordable cities in the US based on its economic prosperity, solid job market, and housing cost.

Minimum Qualifications: Ph.D., M.D., or Ph.D./M.D.

Preferred Qualifications: Competitive individuals will demonstrate proficiency in the analysis of genetic data, high-throughput sequencing data and the use of bioinformatics software. Previous experience with immunological assays, and molecular biology techniques as well as the ability to use UNIX command line programming and R is also considered a plus. Candidates will also demonstrate proficiency in creative thinking, designing experiments independently, interpreting assay results, summarizing findings, and assisting with manuscript preparation, grant writing, supervising graduate students and presenting data at national meetings.
Keywords & fields of study: genomics, epigenomics, complex disease, genetics, bioinformatics, autoimmune diseases