瑞士洛桑大学招收细胞生物学博士后

Post-Doctoral Position to work on cellular stress-sensing mechanisms : University of Lausanne, Switzerland

Our laboratory is working on a physiological stress-induced protective pathway that is regulated by caspase-3, a protease previously known to mediate apoptosis (Khalil et al., 2013, Trends Cell Biol. 24, 83-89). This survival pathway is activated once p120 RasGAP is partially cleaved by the low levels of caspase-3 activity found in stressed cells (Khalil et al., 2012, Mol. Cell Biol. 32, 4523-4533). The resulting N-terminal fragment, called fragment N, stimulates a Ras/PI3K/Akt-dependent anti-apoptotic pathway. Recent data obtained in the laboratory indicate that the caspase-3/RasGAP stress-sensing module also regulates gene transcription and cell metabolism.

We are seeking to recruit a highly motivated Post-Doctoral Fellow to investigate the molecular mechanisms that mediate the activities of the caspase-3/RasGAP stress-sensing module both in vitro and in vivo.

The successful applicant will have a PhD in cell biology, biochemistry or a related biological discipline. Experience in the apoptosis and cell signaling fields, as well as a demonstrated ability to generate publications, would be desirable. Applicants must have experience in several of the following: mouse manipulation, cell culture, generation and use of lentivirus, Western blotting and immunoprecipitation, live cell imaging, confocal and widefield microscopy. Other required qualifications include creativity, the capacity to maintain excellent documentation of their work, to collaborate proficiently, and to communicate effectively with colleagues.

This position is available immediately for 2 years in the first instance with the possibility of extension.
Applications containing a CV, a brief statement of your research experience and interests as well as contact information of 2-3 references should be sent to Pr. Christian Widmann (Christian.Widmann@unil.ch)….