芬兰赫尔辛基大学招收合成生物学博士后

Post-doctoral scientist in synthetic biology (3 years) : Helsinki, Finland

Position available at the laboratory headed by Prof. Jussi Taipale (http://research.med.helsinki.fi/gsb/taipale/) in University of Helsinki for a post-doctoral scientist in the field of synthetic biology. The project funding starts 1st of August, 2014.

The project is part of the ERASynBio project entitled Establishment of a fully synthetic, mirror-image biological system (MirrorBio). The MirrorBio project aims to create a mirror-image synthetic biology: to mimic parts of a biological system entirely independent of nature using artificial component parts. These mirror molecules could prove beneficial in therapeutic use as they are more stable biologically and less immunogenic than their natural counterparts.

The scientist will select transcription factors for D- and L-protein synthesis based on molecular modeling, and design the binding domains and the DNA sequences required for the assay of their specificity and affinity. The person will also be in charge of implementing the SELEX processes on L-DNA aptamers.

Candidates with experience in molecular modeling, SELEX and/or synthetic biology are particularly encouraged to apply. Please send an application containing your CV, publication list and two letters of reference to taipale-applications@helsinki.fi, indicating the project 'MirrorBio' in your application.

Jussi Taipale, Ph.D.
Professor in Medical Systems Biology

Selected publications from Taipale lab:

Turunen et al. (2014) Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity. Cell Rep (Epub ahead of print).

Jolma et al. (2013) DNA-Binding Specificities of Human Transcription Factors. Cell. 152:327-39.

Sur et al. (2012) Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors. Science. 338:1360-3….