Position Title: Pediatric physiologically based pharmacokinetics (PBPK) modeling to guide clinical trial design
At AstraZeneca We are seeking talented scientists who are interested in pursuing an academic-style Postdoc in a global pharmaceutical setting and contributing to AstraZeneca's commitment to delivering innovative medicines. This newly expanded internal pharmaceutical Postdoctoral research program spans multiple therapeutic areas and a wide range of scientific disciplines.
Your comprehensive training program includes a focus on drug discovery and development, as well as exposure to existing local and global Postdoctoral Research communities within AstraZeneca. Postdoctoral scientists will have the opportunity to conduct independent cutting-edge work in state-of-the-art laboratories while teaming with other AstraZeneca scientists.
Each Postdoctoral scientist will also be able to collaborate with a leading academic advisor who will provide further support and guidance. Additionally, the Postdoc will be encouraged to attend and present at international scientific conferences and publish high-profile papers.
Candidate Focus and Challenge
Major responsibilities:
* Perform literature searches and evaluate available clinical pediatric reports
* Collection of both preclinical and clinical adult and pediatric data for identified drugs
* Develop PBPK models and population allometric scaling models with the collected data
* Develop an approach to compare pros and cons of both methodology and propose good practice based on findings
* Validate proposed good practices with emerging data
* Develop skills in both clinical pharmacology and pharmacometrics and it's impact in drug development process especially toward pediatric development
* Willing to develop and freely share new idea to improve or enhance current process
* Actively engaged with all the AZ and academic supervisors
* Collaborate with other scientist within Astrazenca global while able to work solitarily
* Publish scientific papers describing findings from the project and especially any novel method/approaches
Key deliverables:
Delivery of modelling and data analysis methods for the collected data and proposed good practice/recommendation
Requirements
Candidate Knowledge, Skills and Experience
Minimum Requirements:
* A PhD in pharmacokinetics, drug metabolism, pharmacology, mathematics, biomedical engineering or relevant discipline:
Preferred experience
* Pharmacokinetic modelling, physiologically based pharmacokinetic (PBPK) modelling or systems biology modeling.
* Mathematical or statistical modelling with experience in modelling biological data.
* Application of specialist in tools such as SIMCYP, Phoenix, WinNonlin, Matlab, NONMEM, R,
* Understanding of DMPK and pharmacology/safety, drug delivery, pharmacokinetic, pharmacodynamic and pediatric aspects of drug discovery and development
Skills and Capabilities:
* Good team working and networking skills.
* Able to demonstrate the drive and energy to deliver projects.
* Demonstrate a high degree of personal credibility.
* Work collaboratively within a team and networking
* Ability to share knowledge and interpret findings
* Strong interpersonal, organizational and communication skills
* A strong scientific track record, as evidenced by published or accepted papers in peer-reviewed journals, oral and/or poster presentations at scientific meetings
* Strong commitment to science and ability to work well within a group environment
* Good communication skill as the position will require working with colleague in cross-geographic locations.
* Collaborative and interactive personality
Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled/Sexual Orientation
