英国弗朗西斯克里克研究所博士后—胚胎干细胞

英国弗朗西斯克里克研究所博士后—胚胎干细胞

弗朗西斯·克里克研究所（Francis Crick Institute）：2010年诺贝尔奖得主、遗传学家保罗·纳斯提议将英国伦敦两家最大的生物医学研究中心（英国国家医学研究所，英国癌症研究中心）合并在一起，建立一个巨型实验室。

2015年11月实验室将竣工，2021年，这家耗费6.5亿英镑（约63亿人民币）、占地9.3万平方米的研究所将全功率运行，将有1600位科学家和工作人员在这里工作，它将成为欧洲最大的单一生物医学实验室。

Postdoctoral Fellow –Hill lab

Employer

Francis Crick Institute

Location

London (Central), London (Greater) (GB)

Salary

From £43,210 with benefits, subject to skills and experience

Closing date

31 Oct 2024

Postdoctoral Fellow – Hill lab

Reporting to: Caroline Hill, Head of Developmental Signalling Laboratory

Contact term: This is a full-time, fixed term [4 years] position on Crick terms and conditions of employment.

The Research Group

The Developmental Signalling Laboratory headed by Caroline Hill focuses on cell signalling in early vertebrate development and disease - see https://www.crick.ac.uk/research/a-z-researchers/researchers-d-j/caroline-hill/. Their work seeks to understand how TGF-b family signalling pathways function normally in early vertebrate development and in adult untransformed cells, and how these signalling pathways are perturbed in disease, in particular in cancer and the Marfan-related syndromes. Work in the Hill laboratory exploits the very powerful combination of early vertebrate developmental systems (zebrafish embryos), together with a variety of model tissue culture systems (human and mouse ES cell/iPS cell models), and mouse cancer models and uses a very wide range of methodologies including developmental and cell biology, cancer biology, next generation sequencing and computational modelling. The Hill lab encourages creative and independent thinking and promotes excellent training and mentoring. The group currently comprises ten people – five postdocs, two PhD students, a clinical fellow, a master’s student and a senior laboratory research scientist.

For selected recent publications see:

https://pubmed.ncbi.nlm.nih.gov/37714159/

https://pubmed.ncbi.nlm.nih.gov/36473458/

https://pubmed.ncbi.nlm.nih.gov/34737283/

https://pubmed.ncbi.nlm.nih.gov/34003511/

The Project

Recent work in my lab has determined that mesoderm and endoderm specification in zebrafish embryos requires the interplay of two signalling pathways, Nodal and Fgf/Erk. We have shown that the distribution of endodermal progenitors results from a stochastic process where sustained Nodal signalling provides a competency window for the switching of bipotential progenitors to an endodermal fate. Switching is apparently stochastic and is inhibited by Fgf/Erk signalling. Cells that do not switch to the endodermal fate, differentiate to mesoderm. Thus, we hypothesise that short windows of Erk inactivity govern the switching to the endodermal fate and we have shown that these occur as cells undergo mitosis as a result of a phenomenon we are calling mitotic erasure.

We now want to understand whether a similar mechanism controls the cell fate decision between mesoderm and definitive endoderm in humans, and if not, how this fate decision is controlled. To undertake this work, I am looking for a highly motivated postdoc with proven research abilities and an excellent publication record.

The project will make use of human embryonic stem cells (hESCs) differentiated as 2D and 3D gastruloids. We will multiplex our novel Erk biosensor with live cell fate reporters to discover whether and how Erk signalling is involved in the cell fate decision between definitive endoderm and mesoderm. Furthermore, we will use multiomics scRNA-seq and scATAC-seq methodology, as well as whole genome CRISPR screening approaches to gain unbiased new insights into the mechanisms driving the specification of the mesodermal and endodermal lineages in humans.

Postdoctoral Fellows at the Crick lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential.

Key experience and competencies

The post holder should embody and demonstrate our core Crick values:

Bold; Imaginative; Open; Dynamic; Collegial

Essential

PhD in a relevant biological science

Good knowledge and hands on experience of working with embryonic stem cells

Technical expertise in differentiating embryonic stem cells to different tissue types

Technical expertise in live imaging

Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals

Evidence of data presentation at scientific meetings

Strong organisational skills and thorough record-keeping

Ability to work independently and also in a team

Desirable

Experience in signal transduction research

Experience in ‘omics techniques and bioinformatic analysis

About Us

At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.

We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists, and applied scientists from our pharmaceutical partners.

We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.

We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.

If you are interested in applying for this role, please apply via our website.

All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

If you require a visa to work in the UK, we will help support your application should you be successful

Find out what benefits the Crick has to offer:

For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits

Equality, Diversity & Inclusion:

We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.

Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.

The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.

Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion

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