澳大利亚阿德莱德大学博士后—实体癌的新型免疫疗法

澳大利亚阿德莱德大学博士后—实体癌的新型免疫疗法

阿德莱德大学（The University of Adelaide），简称“阿大”，是澳大利亚历史上第三所最古老的大学，2024年QS世界大学排名89位。该校是澳大利亚南澳大利亚州首府阿德莱德的研究型高等学府，也是砂岩学府之一，21世纪学术联盟、澳大利亚八校联盟、英联邦大学协会成员。

Grant-Funded Researcher (A)

The University of Adelaide

Fixed term, full time position available for 24 months.

An opportunity exists for a talented postdoctoral researcher to join the T Cell Immunotherapy Lab (PI Dr Mara Zeissig) to work on novel immunotherapies for the treatment of solid cancers. The applicant should have experience in cellular immunology or cancer immunotherapy.

The Lab's research is focused on understanding how cancers evade the immune system to identify new ways to enhance response to immunotherapy. In particular, we work on cancers that are addicted to the oncogene KRAS such as lung, colorectal and pancreatic cancers. We utilise a range of tools including genetically engineered preclinical models of cancer, analysis of immune cell subsets, single-cell profiling and molecular biology techniques. We also harness large-scale genetic screening using CRISPR-Cas9 technology to find previously unknown targets and mechanisms that regulate response to immunotherapy.

About the project:

In this project, the candidate will be involved in an exciting new discovery project using CRISPR/Cas9 screens to identify new genes that improve T cell persistence and anti-tumour responses. New drug targets identified in the screens will be characterised in vitro and in vivo to assess the effects on tumour growth, immune infiltration and response to immunotherapy.

To be successful you will need:

PhD in Cancer Biology, Immunology or Cancer Immunotherapy (or near completion).

Excellent academic record and research experience that has resulted in publications, conference papers or reports

Experience with cellular immunology, flow cytometry, cell culture and molecular/biochemical techniques

Ability to contribute to a diverse and collaborative team environment and manage time effectively

High quality written and oral communication skills

Applications close 11:55pm, 19 September 2024.

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