美国匹兹堡大学博士后职位—细胞生物学

美国匹兹堡大学博士后职位—细胞生物学

匹兹堡大学（University of Pittsburgh），简称“匹大”（PITT），成立于1787年，美国最早的十所大学之一，被誉为“公立常春藤”，是美国大学协会成员。主校区位于宾夕法尼亚州第二大城市匹兹堡，与卡内基梅隆大学隔街相对，各学院分布在奥克兰区（Oakland），地理位置优越。

Post Doctoral Associate

Med-Cell Biology - Pennsylvania-Pittsburgh - (24001381)

We are looking for enthusiastic scientists to study the role of alpha-synuclein in synaptic health and disease.

The Vargas lab is focus in understanding how alpha-synuclein affects synaptic vesicle recycling by studying the localization, interaction and mechanisms of several endocytic proteins. Some of the proteins we study are clathrin, AP2 and AP180 and how they are affected by alpha-synuclein. We are building a molecular mechanism using imaging with emphasis in high resolution microscopy and biochemistry with a focus on interaction of proteins. Our final goal is to understand how the synaptic deficit driven by alpha-synuclein produces neurodegeneration in diseases such as Parkinson’s disease and Dementia with Lewy Bodies.

We use 2 models, the mouse synapse and the lamprey synapse. Lamprey is a marine animal with a special synapse that allow us to have greater resolution of synaptic proteins. The lab’s most used techniques are cell culture, primary culture of hippocampal neurons, lamprey giant synapse manipulation, fluorescence microscopy, expansion microscopy, biochemistry, and electron microscopy. We are looking forward to implementing more techniques as our research expands. Positions will be advised by Dr. Karina Vargas and will have the opportunity to participate in lab and journal club meetings. Candidates highly motivated to pursue a career in STEM or medicine and interested in conducting more than 1 year of mentored research should apply.

Qualifications: Recent PhD in the biomedical or related field. Preferred Skills: excellent lab and notebook organization, punctuality, teamwork, problem-solving, time management, effective communication. The successful candidates must have a degree that align with the topics we study, such as a degree in biochemistry or biological sciences or engineering.

Prior experience in any aspects of the lab’s research will be advantageous.

You can find some information about us in the links below.

Cell Biology Department webpage: http://www.cbp.pitt.edu

Personal webpage: https://karinajvargas.wixsite.com/website

Lab webpage: www.synapsephysiologylab.com

ResearchGate: https://www.researchgate.net/profile/Karina-Vargas-5

Pittsburgh: https://www.visitpittsburgh.com/

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