丹麦哥本哈根大学博士后职位—糖蛋白和糖胺聚糖的功能分析

丹麦哥本哈根大学博士后职位—糖蛋白和糖胺聚糖的功能分析

哥本哈根大学 （英文: University of Copenhagen; 丹麦文: Københavns Universitet；简称：UCPH / KU）坐落于丹麦王国首都哥本哈根，是丹麦最高学府，4EU＋联盟、国际研究型大学联盟、欧洲研究型大学联盟、欧洲首都大学联盟、欧洲大学协会成员。大学建于1479年，已有500多年历史，从最初只对社会名流开放，现已发展成一所学科全面、集教育与科研于一身的世界研究型大学。

Postdoc in Functional analysis of glycoproteins and glycosaminoglycans at Copenhagen Center for Glycomics

Copenhagen University

Denmark

February 15, 2024

Contact:N/A

Offerd Salary:Negotiation

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Contract Type:fixed-term position

Working Time:Negotigation

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We are offering one or more postdoc positions at the Copenhagen Center for Glycomics (CCG) with the Miller and Schjoldager Groups, commencing from April 1st 2024, or after agreement.

Our research Copenhagen Center for Glycomics (CCG) is composed of 5 research groups and hosts about 10 post docs and 15 PhD students in addition to Master students and guest researchers. CCG strives to be a leader in glycosciences in pioneering the transformation of the field towards wider integration into mainstream cell biology by developing experimental strategies, informatics approaches, and sustainable resources amenable not only to experts. We aim to facilitate the discovery of diseases caused by altered glycosylation, develop new diagnostic and therapeutic tools, and identify new ways to design and produce improved glycoprotein drugs. CCG is a cutting-edge interdisciplinary research and training Center located on the 10th floor of the new Mærsk Tower science building within the Department of Cellular and Molecular Medicine (ICMM). CCG has state-of-the-art facilities for mass spectrometry, mass photometry, flow cytometry, cell engineering, and glycan arrays, and group leaders hold diverse expertise in all areas of glycosciences. Our core valuables include glycoproteome data and bioinformatics tools, validated gene editing tools, glycoengineered cell libraries, and design matrices for the recombinant production of glycotherapeutics. CCG hosts an international seminar series, PhD courses in glycobiology and gene editing, and participates in ICMMs education program. CCG also houses a spin-out (GlycoDisplay ApS) dedicated to developing improved glycoprotein drugs.

One or more postdoc positions are available within the following research programs at CCG in the Department of Cellular and Molecular Medicine (ICMM);

The Miller Group This research program are within the Miller group at CCG at the Department of Cellular and Molecular Medicine (ICMM) driving research project. The Miller group is home to a highly interdisciplinary team, working at the intersection of genomics, molecular biology, technology platforms, and artificial intelligence. One of our studies has just been published in Science, and we are striving for excellence and impact, we aim to do research that pushes the boundaries of human knowledge, and that benefits citizens health.

Job description:

·  The use of cutting-edge technologies in large-scale data analysis (cancer genomics, population genomics), DNA/RNA sequencing (e.g. Nanopore data generation and analysis), gene editing, and artificial intelligence (e.g. DNA and protein language models).

·  We are looking for a talented and motivated researcher with the ability to develop signal processing and machine learning methods to decipher the complex problems of interpreting the signal outputs.

The project will be performed with Oxford Nanopore technologies and the applicant is expected to occasionally travel to Oxford for the project.

Start: April 1st, 2024, or after agreement

Duration: 2 years

Principal supervisor Associate professor Rebecca Miller (rmiller@sund.ku.dk). More information at https: // icmm.ku.dk/english/research-groups/r-miller-group/

The Schjoldager Group This research program are in the Schjoldager group at Copenhagen Center for Glycomics at the Department of Cellular and Molecular Medicine, University of Copenhagen, driving research projects related to the discovery and dissection of biological functions of protein glycosylation with a focus on the identification of specific molecular functions of glycoproteins and glycoconjugates that impact human physiology and common diseases and dispositions to disease.

Job description: Our research team is embarking on a groundbreaking project aiming to validate and understand the role of glycosylation in processes relating to protein secretion.

We are seeking a highly skilled and motivated Research Associate to contribute to the in vivo profiling of glycosylation-dependent protein secretion. The successful candidate will play a key role in the design and execution of experiments involving proximity labelling, generation of cell models, and the use of advanced microscopy as well as mass spectrometry techniques. This position offers a unique opportunity to work on a collaborative and high- impact project in a world leading glycoscience based center.

Start: April 1st, 2024, or after agreement

Duration: 2 years

Principal supervisor Associate Professor Katrine Schjoldager (schjoldager@sund.ku.dk).

More information at https: // icmm.ku.dk/english/research-groups/schjoldager- group/

Profile We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:

Key criteria for the assessment of applicants

·  You have a PhD in glycobiology, informatics, quantitative biology, signal processing/machine learning, or related areas.

·  Previous scientific publications in peer-reviewed journals.

Other important criteria are:

·  Experience using python to develop quantitative or numerical software for real-world applications.

·  Good quantitative understanding of the ideas of applied statistics and machine learning.

·  Proficient communication skills and ability to work in teams.

·  Excellent written and spoken English skills.

Applicants should be highly organized and motivated to carry out research related to the topics described above. Candidates with prior experience in glycobiology, cell biology, structural biology, biophysics, and/or machine learning and data analysis for scientific applications will receive advantaged consideration.

Place of employment The place of employment is at the Department of Cellular and Molecular Medicine (ICMM), University of Copenhagen. ICMM offers a creative and ambitious scientific environment, with many different nationalities represented. ICMM aims to produce research with high international impact focusing on the functional cell, its genetic components, and molecular cellular mechanisms in a medical context. ICMM currently comprises five research programs, three high profile Research Centers as well as several international research groups. The scientists at ICMM are involved in high quality research based undergraduate and graduate teaching programs at the University of Copenhagen.

More information can be found at www. icmm.ku.dk.

Terms of employment The average weekly working hours are 37 hours per week.

The position is a fixed-term position limited to a period of 2 years. The starting date is April 1st 2024, or after agreement.

Salary, pension, and other conditions of employment are set in accordance with the Agreement between the Ministry of Taxation and AC (Danish Confederation of Professional Associations) or other relevant organisation. Currently, the monthly salary for a postdoctoral researcher starts at DKK 36,412 / approx. EUR 4,885 (October 2023 level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Foreign and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The positions are covered by the Job Structure for Academic Staff at Universities 2020.

Questions For further information please contact the hiring group leaders mentioned above.

Foreign applicants may find this link useful: www. ism.ku.dk (International Staff Mobility).

Application procedure Your online application must be submitted in English by clicking ‘Apply now' below. Furthermore, your application must include the following documents/attachments – all in PDF format:

·  Motivated letter of application (max. one page).

·  CV incl. education, work/research experience, language skills, and other skills relevant to the position.

·  A certified/signed copy of a) PhD certificate and b) if applicable a Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.

·  List of publications.

Deadline for applications: Thursday 15 February 2024, 23.59pm CET.

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the above-mentioned requirements.

The further process After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at https: // employment.ku.dk/faculty/recruitment-process/

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

The Faculty of Health and Medical Sciences comprises approximately 7,815 students, 2,113 researchers and 3,793 employees. The faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community.The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position.

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