美国俄亥俄州立大学博士后职位—兽医生物科学

美国俄亥俄州立大学博士后职位—兽医生物科学

俄亥俄州立大学（The Ohio State University），简称OSU，是一所位于俄亥俄州哥伦布市的公立研究型赠地大学。其创建立于1870年，是最早加入美国大学协会的成员之一，被誉为公立常春藤。在美国占地排名第三。

俄亥俄州立大学最初被称为俄亥俄农工学院，专注于各种农业和机械学科。2022年，该大学的捐赠额为70亿美元，是世界上获得最多捐款大学之一。

Post Doctoral Scholar – Veterinary Biosciences

The Ohio State University

Job Description

Department:

Veterinary Medicine | Veterinary Biosciences

Dr. Gaofeng Xiong’s laboratory in the Department of Veterinary Biosciences at The Ohio State University is seeking a motivated candidate for a postdoctoral position.

Dr. Xiong’s research primarily focuses on understanding important molecular mechanisms and biology underlying breast cancer progression, metastasis, therapy resistance and recurrence, as well as identifying novel potential biomarkers and therapeutic targets for breast cancer treatment (Proc Natl Acad Sci U S A 2020 & 2023, Nature Communications 2018, J Biol Chem 2022, Cancer Research 2015 & 2012, ACS Nano 2015, Integrative Biology 2015, Molecular and Cellular Biology 2014). To learn more about this lab's research, please visit the below link:

https://vet.osu.edu/about-us/people/gaofeng-xiong

A Post Doctoral Scholar will be involved in the project investigating the role of P4HA1 in endocrine resistance of breast cancer, which is recently awarded by external funding from NIH-NIA. Resistance to endocrine therapy and recurrence are the leading causes of mortality in breast cancer patients. P4HA1, the alpha subunit of Prolyl hydroxylation (P4H), is an enzyme hydroxylates proline into 4-hydroxyproline of collagens and other proteins with the -X-Pro-Gly- sequences as collagens in the endoplasmic reticulum. This project will focus on the uncanonical role of P4HA1 as a key player coordinates the crosstalk between endocrine resistance and cellular stresses (oxidative stress, endoplasmic reticulum stress), and explore P4HA1 as a novel therapeutic target for endocrine resistant luminal breast cancer. In vitro 2D/3D tissue culture model, in vivo breast cancer cell line and patient-derived xenograft models, as well as conditional knock out mouse model will be used in this project.

Minimum Education Required

Ph.D. in Biology, molecular, or other cell biology-related fields

Essential Qualifications

The candidate will be expected to conduct standard molecular and cellular experiments like PCR, western blots, IHC, IF, FACS, tissue culture, etc.

Desired Qualifications

Xenograft model and transgenic mouse model experiences are desired but not required. Strong writing, analytical, and communication skills are expected.

How to Apply:

Applications should include a CV, representative publications, contact information of references, and a cover letter detailing how your research experiences match this position. Review of applicants will begin immediately and will continue until the position is filled.

To learn more and apply, please visit: https://osujoblinks.com/jitu

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