瑞典斯德哥尔摩大学高通量生物物理学博士后

瑞典斯德哥尔摩大学高通量生物物理学博士后

斯德哥尔摩大学（英文：Stockholm University）创建于1878年，位于瑞典王国首都斯德哥尔摩，公立综合性研究型学府，Mirai、欧洲大学协会、欧洲首都大学联盟成员。该校最初只开设自然科学方面的课程。1904年建立授予学位制度，随后的20年间创建了法律和人文科学学院。大学下属有四个大的科系：法学、人文学科、社会科学和自然科学，为学生求学提供了广泛的选择空间。

Postdoctoral Fellow in High-throughput Biophysics (1-2)

Stockholm University

atthe Department of Biochemistry and Biophysics. Closing date: 10 October 2023.

SciLifeLab (SciLifeLab) is a national center for molecular biosciences with focus on health and environmental research. The center combines frontline technical expertise with advanced knowledge of translational medicine and molecular bioscience. SciLifeLab is a national resource hosted by Karolinska Institutet, KTH Royal Institute of Technology, Stockholm University and Uppsala University. The center also collaborates with several other universities.

The employment will be placed at the Department of biochemistry and biophysics, at Stockholm University.

Project description 1-2 fully funded postdoctoral positions are available in the research lab of Emil Marklund, based at SciLifeLab campus Solna in Stockholm. In the Marklund lab, we investigate how sequence information in biological macromolecules governs recognition, binding, and dynamical structure. We combine high-throughput measurements of molecular binding with simulations and quantitative modeling to gain a physical understanding of life at the molecular level.

We are recruiting 1-2 Postdocs that want to use and develop state of the art methods for studying binding and dynamical structure of DNA, RNA and proteins. Scientific questions in projects can involve, for example, studying specificity in transcription factor - DNA binding, or detecting protein - protein interactions.

Main responsibilities The successful candidate will use and develop methods within one, or preferably multiple, of the following categories:

Sequence library design, molecular cloning and protein purification: Design and preparation of molecular sequence variants for which binding are to be studied in high-throughput. Examples of suitable backgrounds: Molecular biology, protein engineering, biochemistry.

Optical engineering, fluorescence microscopy, image analysis: Development of microscopes and data analysis pipelines used to acquire and quantify high-throughput binding data. Examples of suitable backgrounds: Optical engineering, hardware-software integration, image analysis.

Building quantitative models: Using high-throughput binding data to build sequence dependent predictive deep learning models, and physical mechanistic models (thermodynamic and kinetic models etc.). Examples of suitable backgrounds: Deep learning, programming, mathematics, physics.

You will participate in designing the project according to the overarching goals of the lab and you will be responsible for the implementation. We are an interdisciplinary lab and you will be encouraged to collaborate with other researchers in the team.

Qualification requirements Postdoctoral positions are appointed primarily for purposes of research. Applicants are expected to hold a Swedish doctoral degree or an equivalent degree from another country.

Assessment criteria The degree must have been completed at latest before the employment decision is made, but no more than three years before the closing date. An older degree may be acceptable under special circumstances. Special reasons refer to sick leave, parental leave, elected positions in trade unions, service in the total defense, or other similar circumstances as well as clinical attachment or service/assignments relevant to the subject area.

In the appointment process, special attention will be given to research skills within the categories listed above, where special attention will be given to skills in biophysics, molecular biology, biochemistry, optical engineering and deep learning.

We would also like that you have these qualifications:

A curious and driven personality with a passion for basic research and/or method development.

Good ability to work in a team.

Strong publication record or other evidence of scientific ability and maturity.

Excellent communication skills in English.

Experience in tackling complex scientific problems or method development in at least one of the categories mentioned above.

Terms of employment The position involves full-time employment for a minimum of two years and a maximum of three years, with the possibility of extension under special circumstances. Start date 2023-12-01 or as per agreement.

Stockholm University strives to be a workplace free from discrimination and with equal opportunities for all.

Contact Further information about the position can be obtained from Assistant Professor Emil Marklund, emil.marklund@dbb.su.se.

Union representatives Ingrid Lander (Saco-S), telephone: +46 708 16 26 64, saco@saco.su.se, Alejandra Pizarro Carrasco (Fackförbundet ST/OFR), telephone: +46 8 16 34 89, alejandra@st.su.se, and seko@seko.su.se (SEKO).

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