德国癌症研究中心（DKFZ）细胞和分子生物学以及癌症生物学，或相关的领域博士后招聘

　　德国癌症研究中心（DKFZ）细胞和分子生物学以及癌症生物学，或相关的领域博士后招聘

　　The German Cancer Research Center is the largest biomedical research institution in Germany. With approximately 3,000 employees, we operate an extensive scientific program in the field of cancer research.

　　The National Center of Tumor Diseases (NCT) Dresden is a joint institution of the German Cancer Research Center, the University Hospital Carl Gustav Carus Dresden, the Faculty of Medicine at TU Dresden, and the Helmholtz-Zentrum Dresden-Rossendorf (HZDR). The NCT with sites in Heidelberg and Dresden is the leading oncological center in Germany and shall be expanded to an international center of excellence regarding point-of-care and individualized cancer medicine.

　　The German Cancer Research Center is seeking for the partner site Dresden of the National Center of Tumor Diseases a

　　Postdoc

　　(Ref-No. 2020-0095)

　　The Department „Translational Medical Oncology“ of the German Cancer Research Center (DKFZ) at the National Center for Tumor Diseases (NCT) Dresden and the “Translational Functional Cancer Genomics” group of the DKFZ at the NCTHeidelberg, headed by Prof. Hanno Glimm, focus on the functional and molecular characterization of malignant cell regulation and metastasis formation. Therefore, we established and extensively characterized biobanks of patient-derived in vivo and in vitro cancer models that we utilize to assess clonal dynamics and regulation of tumor-initiating cell (TIC) activity in gastrointestinal cancers (e.g. Cell Stem cell 2011; Cancer Letters 2016; EMBO MolMed 2017; IJC 2017 and 2020; JEM 2017; Nature Genetics 2017, Cells 2019, Cancer Discovery 2018). Our goal is to mechanistically understand the regulation of tumor-initiating cell (TIC) activity as a prerequisite to eradicate cells with TIC activity in human cancer and to develop safe and efficient therapeutic strategies.

　　For functional characterization we have profound expertise in drug screening approaches on primary patient derived tumor models, global insertional mutagenesis gene activation and pooled shRNA knock down screens that allow for the identification of candidate genes potentially critical for proliferation, tumor and metastasis formation. In addition, the department drives a precision oncology program for genomic analysis of patient cancers as a basis for interventional clinical trials (NCT MASTER). This program has demonstrated that whole-exome/genome and RNA sequencing in a clinical setting provides relevant diagnostic information and creates opportunities for pharmacologic intervention and is connected to the research and patient-derived model activities of the department.

　　Description:

　　We are looking for a highly motivated postdoctoral fellow with significant experience in cell and molecular biology as well as cancer research. As a successful candidate you will develop and drive forward projects that aim at identifying and molecularly characterizing novel cancer vulnerabilities in relevant tumor cell models. These projects will contribute to the translation of a better molecular understanding of tumor cell dependencies into novel treatment approaches for cancer patients.

　　Your profile:

　　Applicants should hold a PhD degree in biology/life sciences with an excellent background and track record in cellular and molecular biology as well as cancer biology, or closely related fields. The successful applicant should be highly self-motivated and experienced in pursueing and driving research projects independently as well as in collaborations. An excellent written and oral command of English is essential. Applications should include a CV, cover letter, certificates, expected availability date, a complete list of publications and 2-3 references.

　　We offer:

　　Interesting, versatile workplace

　　International, attractive working environment

　　Campus with modern state-of-the-art infrastructure

　　Salary according to TV-L including social benefits

　　Possibility to work part-time

　　Flexible working hours

　　Comprehensive further training program

　　Access to the DKFZ International Postdoc Program

　　The position is limited to 2 years.

　　The position can in principle be part-time.

　　For further information please contact

　　Julia Dorok, phone 0351-4585527.

　　The German Cancer Research Center is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

　　To apply for a position please use our online application portal (www.dkfz.de).

　　We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebs­forschungs­zentrum, Personal­abteilung, Im Neuen­heimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apolo­gize for any inconvenience this may cause.