西雅图儿童研究所结核病药物研发博士后招聘

　　西雅图儿童研究所结核病药物研发博士后招聘

　　TB remains a serious global health problem and there is an urgent need for new therapeutic agents and an increased understanding of antibiotic resistance. The Parish Lab is looking for a post-doctoral scientist to work on a tuberculosis drug discovery project. The successful candidate will work in a multi-disciplinary research environment interacting with chemists and biologists. The main research project is to determine the mode of action of new compounds classes under development as TB drugs. Work will also involve target identification, confirmation, and validation, as well as determining mechanisms of drug resistance.

　　Description of Responsibilities:

　　Conduct a research and development project

　　Design and implement research plans

　　Work under Biosafety Level 3 conditions with Mycobacterium tuberculosis

　　Troubleshoot and solve experimental and technical problems

　　To prepare and present papers, reports, and presentations of current research work

　　Write manuscripts and assist with grant preparation

　　Write standard protocols and validation data packages

　　Oversee quality control and data integrity

　　May supervise one or more research assistants

　　Specific duties include:

　　Conduct research into mechanism of kill of new inhibitors

　　Use multiple approaches to identify and validate drug targets

　　Research into mode of resistance of new inhibitors

　　Run a wide range of microbiological and cellular assays

　　Culture and genetic manipulation of mycobacteria

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