Postdoctoral Fellow : Aurora, CO, United States

Postdoctoral positions are available immediately to study interactions between RNA viruses and the mammalian host. One position involves basic and translational work on innate immunity to positive-strand RNA viruses. A novel transgenic mouse model we recently developed will be used along with cell culture systems to investigate mechanisms of viral nucleic acid sensing by pattern-recognition receptors such as MDA5, in translational efforts to achieve broad-spectrum protection against microbial pathogens, and to decipher roles of the innate immune system in autoimmunity. Another position involves our ongoing studies of HIV-1 interactions with host cell proteins, including dependency and restriction factors. Applications of site-specific gene targeting to HIV cure are also of interest. For each position, a strongly motivated individual with a relevant Ph.D. degree is sought. Experience in virology, host-pathogen interactions, innate immunity, bioinformatics, or mouse modeling will be valued.