荷兰Hubrecht研究所招聘干细胞再生医学研究博士后

Description of the project
We seek a postdoctoral fellow for a joint project between the labs of Richard Sherwood and Niels Geijsen to help lead a new program in stem cell biology-based regenerative medicine. Work in our lab focuses on using novel computationally-influenced methods to direct stem cells into therapeutically relevant cell types such as pancreatic beta cells and intestinal cell types. Through high-throughput genome editing approaches and computer modeling of resulting genomic data, we seek to understand how transcription factors dictate embryonic stem cell (ES cell) fate determination. Our previous work has identified hierarchical distinctions among transcription factors, including a class of pioneer transcription factors that is uniquely capable of opening chromatin. We are proceeding to systematically define transcription factor functions to establish predictive models of gene regulation.

Requirements
The fellow we seek would conduct the experimental part of the research including using a high-throughput genomic screening platform to understand and manipulate transcription factor activity in differentiating embryonic stem cells. The work is experimental in nature but highly collaborative with computational biologists at Massachusetts Institute of Technology (MIT). Ideal candidates would have a background in stem cells or genomics and a willingness to engage in interdisciplinary research. A Ph.D. in cell/molecular biology or an equivalent field is required. The research project is a partnership with Brigham and Women’s Hospital and Harvard Medical School, and some training will occur in Boston.

Salary
According to “CAO-Nederlandse Universiteiten” (CAO-NU), salary scale negotiable, depending on age and experience scale 10 excluding 8% holiday allowance and an 8,3% year-end bonus. We offer an extensive package of fringe benefits….