瑞典卡罗琳斯卡医学院合成染色质生物学博士后职位

Karolinska Institutet, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics.

Work description
The position is available from 2015 in the newly established Laboratory of Synthetic Stem Cell and Chromatin Biology. Our laboratory will focus on applying new synthetic and chemical biology methods to understand chromatin structure and function. We will be developing tools to engineer proteins in living cells based on genetic code expansion and unnatural amino acid mutagenesis. We will, for example, control and probe chromatin proteins using light-activated and bioorthogonal labelling chemistries. These methods, combined with quantitative, high-throughput, proteomic and genomic read-outs, will allow us to dissect the complex mechanisms governing chromatin dynamics, histone modifications and epigenetic inheritance. The candidate is expected to develop and apply novel methodologies involving molecular biology, chemical biology, mammalian tissue culture, imaging and epigenomic analyses. Team-oriented motivation, project management skills and technical expertise are required.

We will be located within the modern Science for Life Laboratory (SciLifeLab) building on the Karolinska Institutet (KI) campus, Solna, Stockholm, Sweden. SciLifeLab also houses numerous state-of-the art national core facilities. We are additionally supported by the Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics. Karolinska Institutet ranks as one of the world’s leading medical universities, thanks in part to the quality of its research activities, which today account for 40 per cent of all medical research in Sweden

Entry requirements
A PhD in a relevant field is required. Postdoctoral experience is an advantage. A person is eligible for a position as postdoctoral research fellow if he or she has obtained a PhD no more than seven years before the last date of employment as postdoc. The successful applicant will have expertise in molecular and cell biology techniques. Additionaly, a strong background in one or more of the following areas is required: chemistry or chemical biology, stem cell biology, tissue culture, genomics, molecular or computational biology.

Application process
An employment application must contain the following documents in English:

1. A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
2. A complete list of publications
3. A letter of motivation
4. Verifications for crediting of illness, military service, work for labour unions or student organisations, parental leave or similar circumstances
5. Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline)

The application is to be submitted on the MyNetwork recruitment system.

Karolinska Institutet is one of the world´s leading medical universities. Its mission is to contribute to the improvement of human health through research and education. Karolinska Institutet accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country´s broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine.

Pursuant to the regulations of the Swedish National Archives, applications are kept on file for two years after the appointment has gained legal force. The regulations do not apply to attachments that have been printed or otherwise published.

Karolinska Institutet strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

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