美国贝勒大学医学院神经科学与代谢博士后或访学职位

A postdoctoral or visiting scholar position is available immediately at Baylor College of Medicine to investigate the neural control of feeding behavior and etiological mechanisms of obesity and eating disorders in genetic mouse models.

Hypothalamic AgRP neurons are critical for regulation of feeding and body weight, as acute ablation of these cells in adult mice leads to anorexia and profound weight loss (see PMID 21211531). We demonstrated that such anorexic phenotype is fully reversible with the aid of a GABA-A receptor agonist and that GABA release from AgRP neurons onto neurons in the lateral parabrachial nucleus (PBN) is essential for maintenance of appetite and body weight (Cell 2009; PMID 19563755). Furthermore, we identified a novel excitatory hindbrain circuit and associated signaling pathways that mediates appetite (Nature 2012; PMID 22419158).