x 2 (Fixed Term)

Salary: £28,132-£36,661

Reference: PK03047

Closing date: 28 April 2014

Applications are invited from post-doctoral scientists to investigate the mechanisms of cellular actin filament assembly, and their manipulation by invading bacteria like Salmonella. There are currently two positions funded for 5 years by a Wellcome Trust Senior Investigator Award to Prof. Vassilis Koronakis.

The laboratory is well-funded and located the Department of Pathology in central Cambridge. The laboratory has established powerful biochemical membrane reconstitution and cell biology approaches to resolve processes by which cellular signal transduction cascades lead to the formation of actin structures at the host cell membrane. We will exploit these to resolve how virulence effector proteins modulate small-GTPase networks at the membrane to drive bacterial invasion (see our recent work below).

Humphreys et al (2013) Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells. PNAS 110:16880-85

Humphreys et al (2012) Salmonella SopE and host GEF ARNO cooperate to recruit and activate WAVE to trigger bacterial invasion. Cell Host Microbe 11:129-139

Koronakis et al. (2011) WAVE regulatory complex activation by cooperating GTPases Arf and Rac1. PNAS 108:14449-54

Applicants should have a PhD and experience in biochemistry and/or cell biology.

These positions are available immediately. The deadline for applications will be Monday 28 April 2014, but applications will continue to be considered until the positions are filled. Applications should include a current CV.

Specific enquiries can be made to Prof Koronakis on 01223 339766.

Fixed-term: The funds for these posts are available for 5 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.

To apply online for this vacancy and to view further information about the role, please visit:

http://www.jobs.cam.ac.uk/job/3562.

This will take you to the role on the University?s Job Opportunities pages. There you will need to click on the 'Apply online' button and register an account with the University's Web Recruitment System (if you have not already) and log in before completing the online application form.

Any queries regarding these positions should be directed to jobs@path.cam.ac.uk or 01223 333940.

Please quote reference PK03047 on your application and in any correspondence about this vacancy.

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