美国辛辛那提儿童医学中心肥胖和非酒精性脂肪肝研究博士后职位

The Hemostasis and Thrombosis Program in the Division of Experimental Hematology at Cincinnati Children’s Hospital Research Foundation has an opening for a Postdoctoral Fellow. Dr Matthew Flick's laboratory is focused on defining the mechanisms by which hemostatic factors, such as the coagulation proteins prothrombin and fibrinogen, regulate the development of obesity and the downstream disease sequelae of non-alcoholic fatty liver disease (NAFLD). Specific projects include using novel mouse model systems to determine: (i) the mechanisms linking hepatic fibrin deposition to obesity and high fat diet (HFD)-induced liver steatosis and inflammation; and (ii) the contribution of procoagulant vs. anticoagulant-directed thrombin activity to HFD-induced hepatic inflammation and steatosis and assess the capacity of thrombin inhibitors to reduce established NAFLD.