美国南卡罗来纳医科大学博士后职位—癌症生物学与遗传学

美国南卡罗来纳医科大学博士后职位—癌症生物学与遗传学

南卡罗来纳医科大学（The Medical University of South Carolina），于1824年建立于南卡罗来纳州查尔斯顿，当时是一所致力于为内科医生提供培训的小型私立学院。如今南卡罗来纳医科大学已经扩大到一所州立学校，拥有一个医学研究中心和6个专门为健康专业人士、生物医学科学家和其他与健康有关的人员提供广泛教育服务的学院。

Cancer Biology and Genetics post-doc

Medical University of South Carolina

Job Description

Dr. Delaney, PhD, has an opening in his laboratory for a self-motivated and independent Postdoctoral Scholar.

Delaney Lab projects are centered on investigating how chromosomal copy number changes alter cell biology, particularly in the context of cancer using mice and cancer cell lines as model systems. This position requires a post-doctoral fellow to investigate metallothioneins: zinc binding proteins of relatively unknown contribution to cancer initiation and drug response. The scientific culture in the lab is to initially design projects from unbiased genome-wide assays (bioinformatic or –seq technologies) from the highest quality genetic models and work out full mechanistic stories from the outcome.

Delaney Lab projects are centered on investigating how chromosomal copy number changes alter cell biology, particularly in the context of cancer using mice and cancer cell lines as model systems. This position requires a post-doctoral fellow to investigate metallothioneins: zinc binding proteins of relatively unknown contribution to cancer initiation and drug response. The scientific culture in the lab is to initially design projects from unbiased genome-wide assays (bioinformatic or –seq technologies) from the highest quality genetic models and work out full mechanistic stories from the outcome.

The ideal candidate has previous experience in a cancer biology laboratory, however this is not required if the candidate has demonstrated productivity as evidenced by peer-reviewed publications.

Opportunities to learn and use R for bioinformatic data science are also available and encouraged. Dr. Delaney leads the Biological Big Data for Basic Scientists course at MUSC.

The ideal candidate is well-organized and able to create documentation in Word, Excel, and

Google Docs. The Postdoctoral Scholar must be able to work well in a team setting, including

the mentoring of undergraduates and colleagues. Previous experience with mice,

microscopy, metabolic assays, cell culture, and bacterial plasmid preps is desired but not

required. Previous experience with Cas9-directed mutagenesis beyond simple knockouts is

desired but not required.

The candidate must be willing to work with mice and lentivirus in an oncology context.

The candidate is expected to work hard while in the laboratory, however Dr. Delaney’s lab

culture fosters work-life balance.

Job Duties:

20% Molecular biology assays, westerns, RT-qPCR, DNA isolation, microscopy

15% Maintain mouse colony specific to project including genotyping and monitoring

15% Perform mouse experiments, including tumor cell inoculation, chemotherapeutic treatment, dissections, histology, and related molecular biology

10% Genetic manipulation of mouse and human genes using cutting-edge molecular biology techniques, DNA and RNA purification

10% Prepare cell culture samples by transfection and/or lentivirus

10% Participation in shared lab duties, i.e. reagent maintenance and inventory, general equipment/lab maintenance, data management

10% Write and submit highly competitive applications for fellowships and grants relevant to the trainee

5% Scholarly activities- including manuscript preparation, poster and oral presentations at conferences

5% Keep the lab organized and clean

For official application portal, please visit

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