美国德州大学泰勒医学研究中心诚聘2名博士后 - 病毒学/生物物理

德州大学泰勒医学研究中心，病毒-生物物理综合实验室，将于6月开始成立。卢茂林博士在美国耶鲁大学Yale University从事病毒学，生物物理交叉学科的研究多年，并取得了一系列的科研成果，以第一作者/通讯作者发表在 Nature （2019）、Cell Host &Microbe （2020）、Nat.Struct.Mol.Biol.（2020）等。 现诚寻两位具有高度积极性和协作精神的博士后研究人员加盟。泰勒位于德州东北部，气候宜人，安全宜居。

实验室概况：

实验室经费充足，可以对博士后提供长期支持。

研究对象：SARS-CoV-2和HIV-1的表面免疫原/抗原（刺突蛋白）。

研究手段：单分子荧光smFRET，病毒学，生物物理/化学，分子生物学等相关技术。

目前绝大多数HIV和SARS-CoV-2疫苗研究与刺突蛋白有关。对病毒刺突蛋白的全面了解，理解其如何打开人体细胞的大门，如何被抗体识别以及如何隐藏并逃脱免疫检测，对疫苗设计与有效治疗药物的研发有关键作用。

主要研究方向包括：

1）病毒如何进入细胞进行感染，即病毒与细胞膜的融合过程

2）病毒如何逃脱抗体的识别，即了解抗体和刺突蛋白的相互作用，中和机制，逃逸机制

3）病毒如何通过调控表面刺突蛋白的构象分布，动态平衡来实现生物学功能

4）疫苗如何模拟刺突蛋白来诱导免疫系统产生抗体，抗病毒药物如何阻断病毒进入细胞，即基于刺突蛋白的疫苗和药物设计与功能机理

招聘岗位：博士后2名

职位1具备病毒学背景优先考虑；

职位2具备生物物理学、结构生物学、光学背景、编程语言者优先考虑；但均不是必要条件

教育/研究背景要求：

1. 病毒学/微生物学，生物物理，结构生物学、光学，医学，等生物医学, 生命科学领域相关博士学位

2. 具有较好分子生物学基础，懂得基本常规实验操作

3. 有良好的英文读写能力，良好的沟通能力，团队协作精神

4. 有独立思考，刻苦钻研的学术精神

5. 依据美国NIH标准配备薪职 (30万RMB以上)、福利待遇按学校规定、帮助配偶子女解决医疗保险问题，协助解决各类签证问题

联系方式：

对以上职位感兴趣者，请附上简历和研究经历，以及至少两位推荐人的联系方式到：

卢茂林 (目前联系方式 maolin.lu@yale.edu)

https://scholar.google.com/citations?user=sXdQzMgAAAAJ&hl=en

Two post-doctoral research associates in virology and biophysics/biochemistry

Description

A virology-biophysics lab at the University of Texas Health Science Center,  Tyler (UTHSCT), will open in June 2021. The principal investigator has a strong research record in single-molecule imaging of HIV-1 and SARS-CoV-2 surface spikes (Lu et al., 2019, Nature, 568: 415-419; Lu et al., 2020, Cell Host & Microbe, 28: 880-891. e8). The soon-to-be established lab is now seeking two highly motivated and collaborative postdoctoral research associates in either virology or biophysics/biochemistry to join the team. The research spectrum falls into the dynamics-structure-function paradigm of crucial proteins on enveloped viruses, focusing on how viruses modulate their surface spike proteins to evade antibody recognition while mediating the entry of viruses into susceptible cells for infection. Knowledge on this matter is at the core of designing vaccines and antiviral therapies that prevent virus-to-cell virus infection and cell-to-cell virus transmission. The lab will initially work on SARS-CoV-2 and HIV-1 and gradually spread out to other enveloped viruses. Postdoctoral fellows are expected to be semi-independent in constructing research projects under the supervision of the PI.

Successful candidates should have two or more areas of experience as below:

•  Molecular biology skills: molecular cloning, western blots, ELISA, qPCR, etc.

•  Lentiviruses, coronaviruses, or other infectious diseases (strongly encouraged to apply)

•  Single-molecule FRET or single-molecule biophysics (strongly encouraged to apply)

•  Biophysics/Biochemistry/Structural biology skills: protein expression, protein purification, SPR, programing experiences (desirable, but not required), etc.

•  Hands-on experience in biomedical imaging, such as confocal, TIRF, time-resolved fluorescence, TCSPC, etc.

Responsibilities

•  To lead specific projects, perform experiments, analyze data, and interpret results

•  To present results at scientific conferences, prepare manuscripts, and publish findings in peer-reviewed journals.

•  To communicate well with other lab members and collaborators.

Requirements

•  Doctoral degree in one of the life sciences or optics/imaging-related fields

•  Comfortable to work collaboratively and interdisciplinary.

To Apply:

Please email a cover letter explaining relevant work experience, a CV, and the names and contact information for at least two references to:

Maolin Lu, PhD

Assistant Professor

maolin.lu@yale.edu (current contact email)

The University of Texas Health Science Center at Tyler is committed to encouraging good health. As part of its efforts to achieve these goals of a  tobacco-free hiring process, if you are offered a position at The University,  you will be subject to a Pre-Employment Drug Screen for tobacco compounds in compliance with applicable state laws.

University of Texas Health Science Center at Tyler