美国迈阿密大学白血病生物学与表观遗传学研究博士后职位招聘

　　招聘简介：

　　博士后助理（白血病生物学和表观遗传学研究）

　　·迈阿密大学

　　·地点：佛罗里达州迈阿密

　　·工作号码：7057318（参考号：R100028319）

　　·发布日期：2019年5月15日

　　·申请截止日期：开放至填写

　　职位描述

　　西尔维斯特综合癌症中心与迈阿密大学医疗系统和米勒医学院为博士后助理提供了一个令人兴奋的机会。该职位的重点将放在癌症表观遗传学计划中，并将在一个高度协作的环境中工作，研究白血病和正常造血的表观遗传调控的分子机制。

　　我们目前正在寻找具有高度积极性的博士后研究员，他们具有深入的知识和广泛的细胞和分子生物学技能，可以加入实验室。候选人应展示各种实验室技术的专业知识，包括细胞培养和分子生物学分析（分子克隆，细胞增殖分析，FACS亚群分析，稳定和瞬时转染，shRNA和病毒构建体的使用），DNA和RNA的制备和分析（制备质粒，常规PCR和RT-PCR），染色质免疫沉淀（ChIP）测定，生化测定（ELISA，免疫印迹，Co-IP）。项目将包括候选基因的体内和体外建模，以鉴定表观遗传学上沉默的基因，这些基因有助于造血系统恶性肿瘤的发展和使用体外和体内系统表征候选基因。

　　英文原文：

　　Postdoctoral Associate (Leukemia Biology and Epigenetics Research)

　　·         University of Miami

　　·         Location: Miami, FL

　　·         Job Number: 7057318 (Ref #: R100028319)

　　·         Posting Date: May 15, 2019

　　·         Application Deadline: Open Until Filled

　　Job Description

　　The Sylvester Comprehensive Cancer Center with the University of Miami Health System and Miller School of Medicine has an exciting opportunity for a Postdoctoral Associate. The focus of this position will be in the Cancer Epigenetics Program and will work in a highly collaborative environment investigating the molecular mechanisms of epigenetic regulation of leukemia and normal hematopoiesis.

　　We are currently seeking a highly motivated Postdoctoral Associate with in-depth knowledge and extensive skills in cellular and molecular biology to join the lab. The candidates should demonstrate expertise in various lab techniques including cell culture and molecular biology assays (molecular cloning, cell proliferation assay, subpopulation analysis by FACS, stable and transient transfection, use of shRNA and viral constructs), preparation and analysis of DNA and RNA (preparation of plasmids, regular PCR and RT-PCR), chromatin immunoprecipitation (ChIP) assays, biochemical assays (ELISA, immunoblotting, Co-IP). Projects will include in vivo and in vitro modeling of candidate genes to identify epigenetically silenced genes that contribute to the development of hematopoietic malignancies and characterization of candidate genes using in vitro and in vivo systems.

　　Minimum Qualifications

　　Ph.D. or other doctoral-level degree in a relevant field of study, or M.D. Strong molecular biology or cancer biology skills. Previous experience with epigenetics, cancer modeling or hematopoiesis is preferred. Evidence of scholarly ability (record of publication in peer-reviewed journals, etc.) must be presented. Ability to communicate in written and spoken English is required. It is expected that the candidate will have the ability to work independently, design experiments with appropriate controls, collect and tabulate data, publish and present results, as well as to participate in the training of graduate and rotation students in a research laboratory setting.

　　UHealth-University of Miami Health System, South Florida's only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We're the challenge you've been looking for.

　　Patient safety is a top priority. As a result, during the Influenza ("the flu") season (September through April), the University of Miami School of Medicine requires all employees who provide ongoing services to patients, work in a location (all Hospitals and clinics) where patient care is provided, or work in patient care or clinical care areas, to have an annual influenza vaccination. Failure to meet this requirement will result in rescinding or termination of employment.

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