匹兹堡大学癌症免疫学与免疫治疗博士后招聘

　　招聘简介：

　　研究领域：癌症免疫学与免疫治疗

　　职位描述：匹兹堡大学外科肿瘤学部外科系在Kammula实验室为一位才华横溢、充满激情的博士后研究员/助理立即开放。外科肿瘤学的主要目标是通过免疫学、病毒学和分子生物学技术开发治疗癌症的新方法，并将研究结果转化为患者治疗。我们有兴趣招募博士或医学博士/博士候选人，为专注于癌症采用T细胞疗法的实验室工作。详细的实验室研究兴趣见PMID:28395880；PMID:26712692；PMID:26100671；PMID:25424856。

　　博士后研究员将致力于独立和合作的项目，开发用于晚期癌症的过继T细胞免疫疗法。成功的申请者将采用克隆T细胞受体的策略，并用针对恶性肿瘤抗原的TCR基因修饰人类T细胞。利用人T细胞和鼠体内模型进行的体外研究将用于开发和测试新型T细胞疗法。博士后研究员将进行相关研究，以评估抗原特异性T细胞在过继性T细胞免疫治疗的人类临床试验中的转移、持续性和功能。该职位将涉及与聚合酶链反应，克隆，载体设计，以及细胞培养，流式细胞术，细胞间染色，输血，andelisa/elispot的分子工作。

　　英文原文：

　　Research Area: Cancer Immunology and Immunotherapy

　　Position Description: The Department of Surgery, Division of Surgical Oncology at the University of Pittsburgh has an immediate opening in the Kammula Lab for a talented and passionate postdoctoral fellow/associate. The Division of Surgical Oncology’s primary goal is to develop novel methods for treating cancers through immunology, virology, and molecular biology techniques, and to translate research findings into patient treatments. We are interested in recruiting PhD or MD/PhD candidates for a laboratory that focuses on adoptive T cell therapies for cancer.  Please see PMID: 28395880; PMID: 26712692; PMID: 26100671; PMID: 25424856 for detailed lab research interest.

　　The post-doctoral research fellow will work on independent and collaborative projects developing adoptive T cell immunotherapy for advanced cancers. The successful applicant will employ strategies for cloning T cell receptors and genetic modification of human T cells with TCRs specific for antigens expressed by malignancies. In vitro studies using human T cells and in vivo murine models will be used to develop and test novel T cell therapies. The post-doctoral fellow will perform correlative studies to evaluate the transfer, persistence and function of antigen-specific T cells in human clinical trials of adoptive T cell immunotherapy. The position will involve molecular work with PCR, cloning, vector design, as well as cell culture, flow cytometry, intercellular staining, transfections, andELISA/ELISPOT.

　　Candidates that have an interest in mechanistic and translational studies in cancer immunology and immunotherapy are encouraged to apply. The qualified applicants will be required to conduct research, interpret results, prepare manuscripts, and aid in the preparation of grant applications. The required expertise includes all common molecular biology and cellular immunology techniques, molecular cloning, cell culture, and experience with murine in vivo models. The applicant should have command of the English language, good interpersonal skills, critical thinking ability and evidence of experience and good writing skills through first author publications in peer reviewed journals. The applicant should also be proficient in computer software usage including Word, Excel, PowerPoint, and statistical packages.

　　To be considered for one of these positions, please provide a one-page statement of research interest, a current curriculum vitae and contact information for three-references to: surgoncapplicants@upmc.edu.

　　Employer Name: The University of Pittsburgh

　　Position Location: Pittsburgh, PA

　　Disclaimers: The University of Pittsburgh offers competitive compensation and benefits packages. “The University of Pittsburgh is an EEO/AA/M/F/Vets/Disabled employer”.