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美国安德森癌症中心博士后职位
文章来源:知识人网整理       更新时间:2019年04月01日

  招聘简介:

  杨柳青博士和林春茹博士来自MD安德森癌症中心的分子与细胞肿瘤学系,他们对长非编码RNA(lncrnas)在癌症和遗传疾病中的功能性作用很感兴趣。我们已经证明了长非编码RNA在多种信号途径中的分子机制,包括那些调节乳腺癌转移和代谢重编程的途径(Cell 2014,NCB 2016,NCB 2017,Nature Immunol)。在新闻界)实验室也在研究长非编码RNA在代谢紊乱中的功能重要性。我们已经开发了crispr/cas9介导的lncrna编辑/敲除/敲入小鼠模型和转基因小鼠模型。我们最新的项目将使用上述小鼠模型研究lncrnas在乳腺癌/胰腺癌/肺癌和代谢紊乱发展中的功能作用。博士后应掌握生物化学、细胞生物学、免疫学和小鼠遗传学的基本技术。申请者也应该是乐于学习的独立思想家。博士后候选人应该在三个月内加入实验室。工资将基于NIH PostDoc工资标准。 

  英文原文:

  Drs. Liuqing Yang and Chunru Lin, from the Department of Molecular & Cellular Oncology at MD Anderson Cancer Center, are interested in the functional role of long non-coding RNAs (lncRNAs) in cancer and genetic disease. We have demonstrated the molecular mechanisms of long non-coding RNAs in a variety of signaling pathways, including those that regulate breast cancer metastasis and metabolic reprogramming (Cell 2014, NCB 2016, NCB 2017, Nature Immunol. in press). The laboratory is also investigating the functional importance of long noncoding RNAs in metabolic disorders. We have been developed CRISPR/Cas9-mediated lncRNA editing/knockout/knockin mouse models, and transgenic mouse models. Our newest projects will study lncRNAs’ functional roles in the development of breast/pancreatic/lung cancer, and metabolic disorders using the above mentioned mouse models. Postdoc candidates should possess mastery of basic techniques in biochemistry, cell biology, immunology, and mouse genetics. Applicants should also be independent thinkers who are always willing to learn. The postdoc candidates should expect to join the lab in around three months. The salary will be based on the NIH postdoc salary scale.

  Responsibilities:

  • Use cutting-edge methods to seek novel therapy targets for human cancers and metabolic disorders

  • Be responsible for the design and execution of experimental work, data analysis and their written records

  • Attend and present at internal and international meetings

  • Be expected to publish data in top scientific journals

  Job requirements:

  • PhD in Molecular Biology, Biochemistry or related field

  • Outstanding publication record

  • Strong previous experience in biochemistry

  • Prior experience in RNA biology is preferred.

  • Prior experience in genetic mouse models is preferred.

  • Excellent communication with a focus on teamwork is required.

  Please send a letter of intent, curriculum vitae, names and addresses of three to five references, and a brief summary of past research accomplishments and future research plans to:

  Chunru Lin, PhD, Assistant Professor

  The University of Texas MD Anderson Cancer Center

  Department of Lymphoma/Myeloma

  1515 Holcombe Blvd, Unit 0429

  Houston, TX 77030-4009

  Email: clin2@mdanderson.org

  MD Anderson Cancer Center is an equal opportunity employer and does not discriminate on the basis of race, color, religion, age, national origin, sex, sexual orientation, gender identity/expression, disability, veteran status, genetic information, or any other basis protected by federal, state, or local laws, unless such distinction is required by law. All positions at The University of Texas MD Anderson Cancer Center are security sensitive and subject to examination of criminal history record information. Smoke-free and drug-free environment.

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